Methyl 6-chloropyridine-3-carboxylate
Methyl 6-chloropyridine-3-carboxylate (CAS 73781-91-6) is a halogenated pyridine building block with the molecular formula C7H6ClNO2 and a molar mass of 171.58 g/mol. It is a crystalline solid (melting point 86-90 °C) that combines a reactive ring chlorine with a methyl ester, making it a versatile intermediate in pharmaceutical and agrochemical synthesis. Tech Serve Solutions supplies it at 98% assay as a research and manufacturing-grade reagent to laboratories and producers worldwide.
- IUPAC
- Methyl 6-chloro-3-picolinate,Methyl 6-chloronicotinate
- Synonyms
- Methyl 6-chloronicotinateMethyl 6-chloropyridine-3-carboxylateMethyl 6-chloro-3-pyridinecarboxylate6-Chloronicotinic acid methyl esterMethyl 6-chloro-3-picolinate
Pharmaceutical intermediate
Serves as a building block in the multi-step synthesis of active pharmaceutical ingredients and drug candidates. The activated 6-chloro position and ester group allow controlled elaboration of substituted nicotinate scaffolds.
Heterocyclic building block
Used in medicinal and process chemistry as a functionalised pyridine core for assembling more complex heterocyclic structures. The chlorine readily undergoes nucleophilic aromatic substitution and metal-catalysed cross-coupling.
Agrochemical synthesis
Substituted chloronicotinate esters of this type are common precursors in the preparation of crop-protection compounds. It provides a convenient handle for introducing amine, alkoxy and aryl substituents.
Ester and amide chemistry
The methyl ester can be hydrolysed to the corresponding acid or converted to amides and other derivatives, supporting routes to a range of pyridine-3-carboxylic acid analogues.
Laboratory research reagent
Employed in academic and industrial R&D as a reference compound and reagent for method development and exploratory synthesis around the pyridine carboxylate framework.
| Molecular weight | 171.58 |
|---|---|
| Empirical formula | C7H6ClNO2 |
| Assay | 98% |
| Melting point | 86-90 °C(lit.) |
Hazard statements
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 6-chloropyridine-3-carboxylate used for?
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It is used chiefly as a synthetic building block and intermediate in pharmaceutical and agrochemical chemistry. The combination of a displaceable ring chlorine and a methyl ester makes it well suited to nucleophilic substitution, cross-coupling and subsequent ester or amide transformations on the pyridine ring.
What is the CAS number and molecular formula of Methyl 6-chloropyridine-3-carboxylate?
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The CAS number is 73781-91-6 and the molecular formula is C7H6ClNO2, corresponding to a molecular weight of 171.58 g/mol. Its MDL number is MFCD00023420. It is also known as methyl 6-chloronicotinate.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 6-chloropyridine-3-carboxylate at a typical assay of 98% as a research and manufacturing-grade reagent. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis is provided with each batch, and detailed specifications are available on request.
What are the safety and handling precautions for this compound?
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It carries GHS07 (signal word: Warning). The hazard statements are H317 (may cause an allergic skin reaction) and H319 (causes serious eye irritation). Handle with suitable gloves, eye and face protection and a dust mask, avoid skin contact and dust formation, and follow the supplied safety data sheet. If it gets in the eyes, rinse cautiously with water for several minutes and seek medical advice (P280, P305+P351+P338).
How is Methyl 6-chloropyridine-3-carboxylate packed, shipped and exported?
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It is supplied as a solid in tightly sealed containers sized from gram quantities to bulk, with packaging chosen to protect the material in transit. As a water-hazard class 3 (WGK 3) substance it is handled accordingly, and Tech Serve Solutions manages export documentation and compliant international shipping to laboratories and manufacturers worldwide.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will provide a quotation, current availability and lead time. Samples can be arranged for qualification, accompanied by a certificate of analysis and safety data sheet.
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