Methyl 6-bromo-2-chloronicotinate
Methyl 6-bromo-2-chloronicotinate (CAS 1142192-03-7) is a halogenated pyridine ester with the molecular formula C7H5BrClNO2 and a molecular weight of 250.48 g/mol. This dihalogenated nicotinate carries reactive bromo and chloro substituents alongside a methyl ester, making it a versatile heterocyclic building block for chemical synthesis. Tech Serve Solutions supplies it as a research-grade reagent to pharmaceutical, agrochemical and fine-chemical laboratories engaged in medicinal chemistry and pyridine-scaffold development.
- Synonyms
- Methyl 6-bromo-2-chloronicotinateMethyl 6-bromo-2-chloropyridine-3-carboxylate6-Bromo-2-chloronicotinic acid methyl esterMethyl 6-bromo-2-chloro-3-pyridinecarboxylateCAS 1142192-03-7
Heterocyclic building block
Serves as a functionalised pyridine scaffold in multistep organic synthesis, where the bromo, chloro and ester groups provide distinct handles for sequential, selective transformations.
Pharmaceutical intermediate
Used in medicinal-chemistry research and the preparation of pyridine-based drug intermediates and candidate molecules. Specific downstream targets depend on the customer's synthetic route.
Cross-coupling chemistry
The carbon-bromine bond is well suited to palladium-catalysed couplings such as Suzuki, Stille and Buchwald-Hartwig reactions, allowing controlled introduction of aryl, heteroaryl or amino groups.
Nucleophilic substitution
The chlorine adjacent to the ring nitrogen is activated toward nucleophilic aromatic substitution, enabling installation of amines, alkoxides and other nucleophiles onto the pyridine core.
Ester-derived elaboration
The methyl ester can be hydrolysed, amidated or reduced to access the corresponding carboxylic acid, amides or alcohols, extending the molecule's utility in library and route design.
| Molecular weight | 250.48 |
|---|---|
| Empirical formula | C7H5BrClNO2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 6-bromo-2-chloronicotinate used for?
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It is used principally as a heterocyclic building block and pharmaceutical intermediate in organic and medicinal-chemistry research. Its reactive bromo, chloro and methyl-ester groups make it valuable for cross-coupling, nucleophilic substitution and ester elaboration when constructing more complex pyridine derivatives.
What is the CAS number and molecular formula of Methyl 6-bromo-2-chloronicotinate?
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The CAS number is 1142192-03-7 and the molecular formula is C7H5BrClNO2, with a molecular weight of 250.48 g/mol. It is a dihalogenated methyl nicotinate (methyl pyridine-3-carboxylate) bearing bromine at the 6-position and chlorine at the 2-position.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 6-bromo-2-chloronicotinate as a research/technical-grade reagent suitable for synthesis. We do not represent it as USP, BP or EP pharmacopoeia grade. A current Certificate of Analysis stating the specific assay and lot details is provided with each shipment on request.
How should Methyl 6-bromo-2-chloronicotinate be handled and stored?
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Handle in accordance with good laboratory practice using suitable personal protective equipment, including gloves and eye protection, and work in a well-ventilated area or fume hood. Store the sealed container in a cool, dry place away from incompatible materials. As formal GHS classification data is not specified for this item, treat it as a potential irritant and consult our current Safety Data Sheet before use.
How is Methyl 6-bromo-2-chloronicotinate packed, shipped and exported?
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It is packed in tightly sealed, appropriately labelled containers sized to the order, from gram quantities to larger research volumes. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international documentation and dispatch, with packaging selected to protect the material in transit.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, intended purity and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged subject to stock and regulatory requirements.
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