Methyl 6-fluoropyridine-2-carboxylate
Methyl 6-fluoropyridine-2-carboxylate (CAS 455-71-0; C7H6FNO2; molar mass 155.13 g/mol) is a fluorinated heterocyclic building block, also known as methyl 6-fluoropicolinate. It is a low-melting crystalline solid combining a reactive ester with a ring fluorine on the pyridine scaffold. Tech Serve Solutions supplies it at 97% assay as a research-grade intermediate for pharmaceutical, agrochemical and fine-chemical synthesis, where it serves in amidation, ester hydrolysis and selective functionalisation of the fluoropyridine core.
- IUPAC
- Methyl 6-fluoropicolinate
- Synonyms
- Methyl 6-fluoropicolinateMethyl 6-fluoropyridine-2-carboxylate6-Fluoropyridine-2-carboxylic acid methyl ester6-Fluoro-2-pyridinecarboxylic acid methyl esterMethyl 6-fluoro-2-pyridinecarboxylate
Pharmaceutical intermediate
Used as a fluorinated pyridine building block in medicinal chemistry and the synthesis of active pharmaceutical ingredients. The ring fluorine and ester handle allow controlled elaboration of drug-like fragments.
Agrochemical synthesis
Serves as an intermediate towards crop-protection compounds, where fluoropyridine motifs are valued for metabolic stability and tuned electronic properties.
Ester and amide chemistry
The methyl ester is readily hydrolysed to 6-fluoropicolinic acid or converted to amides and other carboxylic-acid derivatives, providing a versatile entry point for further coupling.
Fluorinated heterocyclic building block
Employed in discovery and process chemistry to install a 6-fluoropyridine-2-carbonyl unit, supporting structure-activity studies and library synthesis.
Laboratory research reagent
Supplied for use as a reference and synthetic reagent in academic and industrial research laboratories undertaking heterocyclic and organofluorine chemistry.
| Molecular weight | 155.13 |
|---|---|
| Empirical formula | C7H6FNO2 |
| Assay | 97% |
| Melting point | 51-55 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 6-fluoropyridine-2-carboxylate used for?
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It is used primarily as a fluorinated heterocyclic building block in pharmaceutical, agrochemical and fine-chemical synthesis. Its reactive methyl ester and ring fluorine make it useful for amidation, ester hydrolysis to the corresponding acid, and selective functionalisation of the pyridine core.
What is the CAS number and molecular formula of Methyl 6-fluoropyridine-2-carboxylate?
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The CAS number is 455-71-0 and the molecular formula is C7H6FNO2, with a molecular weight of 155.13 g/mol. It is also commonly known as methyl 6-fluoropicolinate.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 6-fluoropyridine-2-carboxylate at a typical assay of 97% as a research/technical-grade synthetic intermediate. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and specifications can be confirmed on request.
What are the safety and handling requirements?
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It is classified under GHS07 with the signal word Warning and carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves and eye protection, use a dust mask (type N95) where dust may form, and work with adequate ventilation. In case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present. The material is a low-melting solid (51-55 degC) with a flash point above 110 degC.
How is Methyl 6-fluoropyridine-2-carboxylate packed, shipped and exported?
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It is packed in tightly closed, appropriately labelled containers sized from gram quantities to bulk, kept cool and dry. Tech Serve Solutions exports worldwide with full documentation, including a certificate of analysis and safety data sheet. Packaging and transport are arranged to suit the order quantity and destination requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will provide a quotation, lead time and available documentation. Samples can be arranged for qualification subject to availability.
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