m-Tolyl isocyanate
m-Tolyl isocyanate (CAS 621-29-4, CH3C6H4NCO) is a chemical intermediate with a molecular weight of 133.15 g/mol. This compound functions as a valuable building block in organic synthesis, particularly for creating complex molecules. It is primarily utilised as a reagent in the development of pharmaceutical agents and other fine chemicals, requiring careful handling due to its reactive nature.
- IUPAC
- 3-Methylphenyl isocyanate
- Synonyms
- 3-Methylphenyl isocyanatem-Tolyl isocyanate
Synthesis of Pharmaceutical Intermediates
m-Tolyl isocyanate serves as a key reagent in the synthesis of complex organic molecules, including intermediates for potential pharmaceutical agents. For example, it was used in the synthesis of a cholecystokinin antagonist.
Organic Building Block
As an organic building block, this isocyanate derivative is employed in various chemical synthesis pathways. Its reactivity allows for the introduction of the m-tolyl group into target molecules.
Research and Development
This compound is utilised in research laboratories for exploring new synthetic routes and developing novel chemical entities. Its specific functional group makes it suitable for diverse organic transformations.
| Molecular weight | 133.15 |
|---|---|
| Linear formula | CH3C6H4NCO |
| Assay | 99% |
| Boiling point | 75-76 °C/12 mmHg(lit.) |
| Density | 1.033 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5305(lit.) |
| Storage temperature | 2-8°C |
| Application | m-Tolyl isocyanate was used as reagent during the synthesis of C5-cyclohexyl analog of the cholecystokinin type-B receptor antagonist L-365,2601. |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H330Fatal if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26-36/37/38-42 |
| Safety statements (S) | 23-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is m-Tolyl isocyanate used for?
+
m-Tolyl isocyanate is primarily used as a reagent and building block in organic synthesis, notably in the development of pharmaceutical intermediates.
What are the CAS number and formula for m-Tolyl isocyanate?
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The CAS number for m-Tolyl isocyanate is 621-29-4, and its molecular formula is CH3C6H4NCO.
What grade and purity does Tech Serve Solutions supply for m-Tolyl isocyanate?
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Tech Serve Solutions supplies m-Tolyl isocyanate with an assay of 99%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the primary safety hazards associated with m-Tolyl isocyanate?
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m-Tolyl isocyanate is a danger to health and may cause severe respiratory irritation and allergic skin reactions. It is toxic if inhaled and causes skin and serious eye irritation. Appropriate personal protective equipment, including respiratory protection and chemical-resistant gloves, must be used.
How is m-Tolyl isocyanate packed, shipped, and exported?
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m-Tolyl isocyanate is carefully packed according to international regulations for hazardous materials. Tech Serve Solutions is an experienced global exporter of fine chemicals, ensuring compliant and efficient delivery worldwide.
How can I request a sample or quote for m-Tolyl isocyanate?
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To request a sample or a quote for m-Tolyl isocyanate, please contact our sales team through the enquiry form on our website or call us directly.
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