m-Toluoyl chloride
m-Toluoyl chloride (CAS 1711-06-4), with the linear formula CH₃C₆H₄COCl and a molecular weight of 154.59 g/mol, is a reactive acid halide. It serves as a key intermediate in chemical synthesis and a derivatization reagent. Its primary applications involve the preparation of amides and esters, and it is specifically utilised for determining aliphatic amines and atmospheric ammonia via High-Performance Liquid Chromatography (HPLC).
Derivatization Reagent for Amine Analysis
m-Toluoyl chloride is employed to derivatize C₁-C₄ aliphatic amines, facilitating their determination in air samples using HPLC. This application is crucial for environmental monitoring and occupational health assessments.
Atmospheric Ammonia Determination
This compound is utilised in analytical methods for quantifying atmospheric ammonia. By employing denuder-sampling followed by HPLC-UV detection, m-Toluoyl chloride enables precise measurement of ammonia concentrations in ambient air.
Organic Synthesis Building Block
As a functionalised aromatic compound, m-Toluoyl chloride acts as a versatile building block in organic synthesis. It readily reacts with nucleophiles to form esters, amides, and other derivatives, contributing to the synthesis of more complex molecules.
| Molecular weight | 154.59 |
|---|---|
| Linear formula | CH3C6H4COCl |
| Assay | 99% |
| Boiling point | 86 °C/5 mmHg(lit.) |
| Density | 1.173 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5485(lit.) |
| Application | m-Toluoyl chloride has been used to derivatize the C1-C4 aliphatic amines for their determination in air by HPLC1. It has been used in determination of atmospheric ammonia by denuder-sampling and HPLC-UV detection2. |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 77 °C / 170.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is m-Toluoyl chloride primarily used for?
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m-Toluoyl chloride is primarily used as a derivatization reagent for the determination of aliphatic amines and atmospheric ammonia using HPLC, and as a building block in organic synthesis.
What are the CAS number and molecular formula for m-Toluoyl chloride?
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The CAS number for m-Toluoyl chloride is 1711-06-4, and its linear formula is CH₃C₆H₄COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies m-Toluoyl chloride with a minimum assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should m-Toluoyl chloride be handled safely?
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m-Toluoyl chloride is a corrosive substance that can cause severe skin burns and eye damage, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area. Refer to the Safety Data Sheet for detailed handling instructions.
How is m-Toluoyl chloride packed and shipped?
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m-Toluoyl chloride is packed and shipped in compliance with relevant regulations for hazardous materials. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of m-Toluoyl chloride, please contact our sales team through the TSS website or by phone.
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