m-Toluenesulfonyl chloride
m-Toluenesulfonyl chloride (CAS 1899-93-0, C7H7ClO2S) is a crucial organic compound with a molecular weight of 190.65 g/mol. This sulfonyl halide serves as a valuable reactant in the synthesis of various biologically active molecules. Its utility is demonstrated in the development of ligands, enzyme inhibitors, and antibacterial agents, making it a key intermediate in pharmaceutical and chemical research.
- IUPAC
- 3-Methylbenzenesulfonyl chloride
Synthesis of Biologically Active Molecules
m-Toluenesulfonyl chloride is a key reactant in the preparation of numerous biologically active compounds. It has been employed in the synthesis of small molecule ligands targeting the Stat3 SH2 domain and isoindoline-5-propenehydroxamates which act as histone deacetylase inhibitors.
Development of Kinase Inhibitors
This compound is utilised in the creation of novel therapeutic agents. Specifically, it has been used in the synthesis of phenyl-pyrazolylamine-based derivatives identified as FLT3 kinase inhibitors and quinazoline analogues for the treatment of Gaucher disease.
Antibacterial Agents and Enzyme Inhibitors
m-Toluenesulfonyl chloride finds application in the development of compounds with antimicrobial properties and agents targeting specific enzymes. Examples include the synthesis of aryldisulfonamides with demonstrated antibacterial activity and 17β-HSD2 inhibitors for osteoporosis treatment.
| Molecular weight | 190.65 |
|---|---|
| Linear formula | CH3C6H4SO2Cl |
| Assay | 97% |
| Boiling point | 252-253 °C(lit.) |
| Density | 1.314 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5490(lit.) |
| Application | Reactant involved in they synthesis of biologically active molecules including:• Small molecule ligands for the Stat3 SH2 domain1• Isoindoline-5-propenehydroxamates for use as histone deactylase inhibitors2• Phenyl-pyrazolylamine-based derivatives as FLT3 kinase inhibitors3• Aryldisulfonamides with antibacterial activity4• Quinazoline analogs for the treatment of Gaucher disease5• 17β-HSD2 inhibitors for the treatment of osteoporosis6 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 107 °C / 224.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is m-Toluenesulfonyl chloride used for?
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m-Toluenesulfonyl chloride is used as a reactant in the synthesis of biologically active molecules, including small molecule ligands, enzyme inhibitors, and antibacterial agents. It is a valuable intermediate in pharmaceutical and chemical research.
What are the CAS number and chemical formula for m-Toluenesulfonyl chloride?
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The CAS number for m-Toluenesulfonyl chloride is 1899-93-0, and its chemical formula is CH3C6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies m-Toluenesulfonyl chloride with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should m-Toluenesulfonyl chloride be handled safely?
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m-Toluenesulfonyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including faceshields, gloves, goggles, and suitable respiratory protection, must be used. Handle in a well-ventilated area and follow all safety precautions.
How is m-Toluenesulfonyl chloride packed, shipped, and exported?
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m-Toluenesulfonyl chloride is packed and shipped in compliance with all relevant regulations for hazardous materials. As a global supplier and exporter, Tech Serve Solutions ensures adherence to international shipping standards for chemical products.
How can I request a sample or quote for m-Toluenesulfonyl chloride?
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To request a sample or obtain a quote for m-Toluenesulfonyl chloride, please contact our sales department through the details provided on our website. We are happy to assist with your research and procurement needs.
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