Lithium dimethylamide
Lithium dimethylamide (CAS 3585-33-9) is a highly reactive organolithium compound with the linear formula (CH₃)₂NLi and a molecular weight of 51.02 g/mol. It is a powerful base and nucleophile, commonly supplied as a solution in hexanes. It finds critical use in organic synthesis as a strong base for deprotonation reactions and as a reagent in various chemical transformations.
Strong Base in Organic Synthesis
Lithium dimethylamide serves as a potent, non-nucleophilic base for selective deprotonation in complex organic syntheses. Its high basicity facilitates the generation of carbanions and other reactive intermediates for subsequent functionalisation.
Reagent for Polymerisation
This organolithium compound can act as an initiator or catalyst in certain polymerisation processes. It is employed in the controlled synthesis of polymers requiring specific molecular weights and architectures.
Deprotonation Agent
It is widely used for the deprotonation of weakly acidic C-H bonds, enabling the formation of organometallic species for further reactions, such as alkylations or additions.
| Molecular weight | 51.02 |
|---|---|
| Linear formula | (CH3)2NLi |
| Assay | 95% |
| Boiling point | 68-70 °C |
| Density | 0.68 g/mL at 25 °C |
| Concentration | 5 wt. % in hexanes |
Hazard statements
- H250Catches fire spontaneously if exposed to air
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3393 4.2(4.3) |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 17-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lithium dimethylamide used for?
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Lithium dimethylamide is primarily used as a strong base in organic synthesis for deprotonation reactions, as a nucleophile, and in certain polymerisation processes.
What are the CAS number and formula for Lithium dimethylamide?
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The CAS number for Lithium dimethylamide is 3585-33-9, and its linear formula is (CH₃)₂NLi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Lithium dimethylamide with an assay of 95%. This product is offered as a technical grade for research and synthetic purposes and is not represented as USP, BP, or EP grade.
How should Lithium dimethylamide be handled safely?
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Lithium dimethylamide is highly reactive, pyrophoric, and corrosive. It must be handled under an inert atmosphere (e.g., nitrogen or argon) with appropriate personal protective equipment, including eyeshields, face shields, and chemically resistant gloves. Refer to the Safety Data Sheet for detailed handling procedures.
How is Lithium dimethylamide packed and shipped?
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Lithium dimethylamide is typically supplied as a 5 wt. % solution in hexanes. It is packaged in containers suitable for pyrophoric and water-reactive substances and is shipped in accordance with international regulations for hazardous materials.
How can I request a quote or sample for Lithium dimethylamide?
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To request a quote or sample of Lithium dimethylamide, please contact our sales team via the website or email, providing your specific requirements and shipping details.
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