Lithium diisopropylamide
Lithium diisopropylamide (CAS: 4111-54-0), with the linear formula [(CH3)2CH]2NLi, is a strong, non-nucleophilic base widely used in organic synthesis. Its steric bulk makes it an excellent choice for deprotonation reactions where nucleophilic attack is undesirable. This organolithium compound is crucial for generating enolates, facilitating alkylation, aldol reactions, and various condensation processes. Supplied by Tech Serve Solutions as a 2.0 M solution in THF/heptane/ethylbenzene, it is essential for precise chemical transformations in research and development.
- IUPAC
- LDA
![Lithium diisopropylamide ([(CH3)2CH]2NLi) — chemical structure, CAS 4111-54-0; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F4111-54-0.png&w=3840&q=75)
Enolate Formation
Lithium diisopropylamide is a powerful base for the quantitative deprotonation of carbonyl compounds, esters, and amides to form corresponding enolates. These enolates are key intermediates in carbon-carbon bond-forming reactions.
Alkylation and Acylation
It facilitates the regioselective alkylation and acylation of enolates, enabling the synthesis of complex organic molecules. Its non-nucleophilic nature minimises unwanted side reactions.
Directed Ortho Metalation
LDA can be used in directed ortho metalation reactions, where it selectively deprotonates aromatic rings adjacent to directing groups, enabling functionalisation at specific positions.
Deprotonation of Weakly Acidic Protons
This strong base is capable of removing protons from weakly acidic substrates, such as terminal alkynes and certain heterocycles, enabling further synthetic elaborations.
| Molecular weight | 107.12 |
|---|---|
| Linear formula | [(CH3)2CH]2NLi |
| Assay | 97% |
| Density | 0.864 g/mL at 25 °C(lit.) |
| Concentration | 2.0 M in THF/heptane/ethylbenzene |
| Vapour density | >1 (vs air) |
| Storage temperature | 2-8°C |
| Impurities tested | 3 wt. % diisopropylamine |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Flash point | -23 °C / -9.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 63-11-14-34-62 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lithium diisopropylamide (LDA) used for?
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Lithium diisopropylamide (LDA) is primarily used as a strong, non-nucleophilic base in organic synthesis for deprotonation reactions, such as enolate formation, alkylation, and directed ortho metalation.
What is the CAS number and formula for Lithium diisopropylamide?
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The CAS number for Lithium diisopropylamide is 4111-54-0, and its linear formula is [(CH3)2CH]2NLi.
What grade and purity does Tech Serve Solutions supply for Lithium diisopropylamide?
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Tech Serve Solutions supplies Lithium diisopropylamide with an assay of 97%, containing approximately 3 wt. % diisopropylamine as an impurity. This product is not represented as USP, BP, or EP grade.
How should Lithium diisopropylamide be handled safely?
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Lithium diisopropylamide is flammable and corrosive (H225, H314). Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment including gloves, eye protection, and protective clothing. Avoid contact with skin, eyes, and clothing. Keep away from heat, sparks, and open flames. Ensure proper procedures for handling pyrophoric and moisture-sensitive materials are followed.
How is Lithium diisopropylamide packed and exported by TSS?
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Lithium diisopropylamide is supplied as a 2.0 M solution in THF/heptane/ethylbenzene and is shipped according to UN 2924, 8(3), Packing Group II regulations for hazardous materials. TSS is an experienced global exporter.
How can I request a sample or quote for Lithium diisopropylamide?
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To request a sample or a quote for Lithium diisopropylamide, please contact our sales team through the website or by phone, providing your specific requirements.
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