L-Pipecolic acid
L-Pipecolic acid (CAS: 3105-95-1, C6H11NO2) is a non-proteinogenic amino acid with a molecular weight of 129.16 g/mol. It is a derivative of proline, featuring a six-membered ring. This compound is valued in chemical synthesis and research for its unique structure, finding application in peptide chemistry and as a building block for more complex molecules. Its chiral nature also makes it important in stereoselective synthesis.
- IUPAC
- (S)-(−)-2-Piperidinecarboxylic acid,L-Homoproline
- Synonyms
- L-Homoproline(S)-(-)-2-Piperidinecarboxylic acid

Chemical Synthesis
L-Pipecolic acid serves as a valuable chiral building block in organic synthesis, particularly for creating complex heterocyclic compounds and modified peptides.
Peptide Chemistry
As a non-proteinogenic amino acid, it can be incorporated into peptides to confer unique structural properties and biological activities.
Biochemical Research
Utilised in biochemical and cell biology studies to investigate metabolic pathways or as a component in biochemical assays.
Nutritional Research
Investigated for its potential roles or as a marker in nutrition research due to its structural similarity to proline.
| Molecular weight | 129.16 |
|---|---|
| Empirical formula | C6H11NO2 |
| Assay | ≥99.0% (NT) |
| Optical activity | [α]20/D −26±1°, c = 4% in H2O |
| Melting point | 272 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-Pipecolic acid used for?
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L-Pipecolic acid is primarily used in chemical synthesis as a chiral building block, in peptide chemistry for developing modified peptides, and in biochemical research.
What are the CAS number and formula for L-Pipecolic acid?
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The CAS number for L-Pipecolic acid is 3105-95-1, and its molecular formula is C6H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-Pipecolic acid with an assay of ≥99.0% (NT). We do not represent this product as USP, BP, or EP grade.
How should L-Pipecolic acid be handled safely?
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L-Pipecolic acid is classified as irritating to the skin, eyes, and respiratory system (H315, H319, H335). Handle with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation.
Is L-Pipecolic acid a controlled substance?
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Based on the provided data, L-Pipecolic acid is not indicated as a controlled substance.
How is L-Pipecolic acid shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, adhering to all regulations for the safe and compliant shipment of L-Pipecolic acid worldwide.
How can I request a sample or quote for L-Pipecolic acid?
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Please contact our sales team via the website or direct email to request a sample or a quotation for L-Pipecolic acid.
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