L-Homoarginine hydrochloride
L-Homoarginine hydrochloride (CAS: 1483-01-8), with the molecular formula H₂NC(=NH)NH(CH₂)₄CH(NH₂)CO₂H · HCl and a molecular weight of 224.69 g/mol, is an unnatural amino acid derivative. It serves as a valuable tool in biochemical research, particularly for creating proteins resistant to enzymatic cleavage by trypsin. This substitution can elucidate protein function and structural requirements.
- IUPAC
- (S)-2-Amino-6-guanidinohexanoic acid hydrochloride
Proteolysis Resistance Studies
L-Homoarginine hydrochloride can be incorporated into proteins to render them resistant to digestion by trypsin. This is crucial for understanding protein structure-function relationships by protecting specific arginine residues.
Enzyme Active Site Elucidation
By replacing natural arginine residues, often found in enzyme active sites, with homoarginine, researchers can investigate the enzyme's catalytic mechanisms and structural dependencies.
Peptide and Protein Chemistry
As a homo-amino acid derivative, it is used in the synthesis of modified peptides and proteins for various research applications in chemical biology and peptide chemistry.
| Molecular weight | 224.69 |
|---|---|
| Linear formula | H2NC(=NH)NH(CH2)4CH(NH2)CO2H · HCl |
| Solubility | H2O: soluble |
| Application | The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements. |
| Melting point | 213-215 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-Homoarginine hydrochloride used for?
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L-Homoarginine hydrochloride is used in biochemical research to create proteins resistant to trypsin proteolysis, aiding in the elucidation of protein function and structural requirements, especially when arginine residues are located at active centers.
What are the CAS number and chemical formula for L-Homoarginine hydrochloride?
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The CAS number for L-Homoarginine hydrochloride is 1483-01-8, and its linear formula is H₂NC(=NH)NH(CH₂)₄CH(NH₂)CO₂H · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-Homoarginine hydrochloride based on available specifications. Please refer to the product details for precise assay information. TSS does not represent this product as USP, BP, or EP grade unless explicitly stated.
What are the safety considerations for handling L-Homoarginine hydrochloride?
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Handling L-Homoarginine hydrochloride requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The WGK (German water hazard class) is 3.
How is L-Homoarginine hydrochloride packed and shipped?
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L-Homoarginine hydrochloride is carefully packed according to industry standards for safe transport and export. Detailed shipping information is available upon request.
How can I request a sample or quote for L-Homoarginine hydrochloride?
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To request a sample or a quote for L-Homoarginine hydrochloride, please contact our sales department through the website or by phone.
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