Isopropyllithium solution
Isopropyllithium solution (CAS: 1888-75-1), with the linear formula (CH3)2CHLi and a molecular weight of 50.03 g/mol, is a vital organometallic reagent. Supplied as a 0.7 M solution in pentane, it is a powerful base and nucleophile. This reagent is crucial in organic synthesis for reactions such as alkylations and deprotonations, particularly in the synthesis of complex organic molecules and pharmaceutical intermediates.
Organic Synthesis
Isopropyllithium solution serves as a strong base for deprotonation reactions and as a nucleophile in alkylation and addition reactions, enabling the formation of carbon-carbon bonds in complex molecular architectures.
Synthesis of Amino Alcohols
It is employed in the alkylative ring opening of N-sulfonyl protected aziridines, a process that yields valuable amino alcohols and ethers, essential building blocks in pharmaceutical research.
Organometallic Chemistry
As an organolithium compound, it participates in fundamental organometallic transformations, facilitating the synthesis of a wide array of organic compounds.
| Molecular weight | 50.03 |
|---|---|
| Linear formula | (CH3)2CHLi |
| Boiling point | 35-36 °C |
| Density | 0.632 g/mL at 25 °C |
| Concentration | 0.7 M in pentane |
| Storage temperature | 2-8°C |
| Application | Used in a study of the alkylative ring opening of N-sulfonyl protected aziridines providing amino alcohols and ethers.1 |
Hazard statements
- H224Extremely flammable liquid and vapour
- H304May be fatal if swallowed and enters airways
- H315Causes skin irritation
- H318Causes serious eye damage
- H336May cause drowsiness or dizziness
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Flash point | -35 °C / -31 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 3/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn,N |
| Risk statements (R) | 11-51/53-65-66-67 |
| Safety statements (S) | 16-61-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isopropyllithium solution used for?
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Isopropyllithium solution is primarily used as a strong base and nucleophile in organic synthesis, including alkylative ring opening of aziridines to form amino alcohols and ethers.
What are the CAS number and formula for Isopropyllithium solution?
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The CAS number is 1888-75-1 and the linear formula is (CH3)2CHLi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isopropyllithium solution as a 0.7 M concentration in pentane. We do not represent this product as USP, BP, or EP grade; it is supplied for research and technical applications.
How should Isopropyllithium solution be handled and stored?
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Isopropyllithium solution is highly flammable and corrosive. It requires careful handling under inert atmosphere due to its pyrophoric nature. Store at 2-8°C, away from ignition sources, and incompatible materials. Refer to the Safety Data Sheet for detailed handling instructions.
How is Isopropyllithium solution packed and shipped?
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This product is supplied in Sure/Seal reagent bottles designed for safe handling of air- and moisture-sensitive reagents. It is exported globally following all relevant dangerous goods regulations.
How can I request a quote or sample for Isopropyllithium solution?
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To request a quote or a sample, please contact our sales department through the TSS website or by phone, providing your required quantity and shipping details.
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