Isobutyllithium solution
Isobutyllithium solution (CAS 920-36-5) is a highly reactive organolithium reagent with the linear formula (CH3)2CHCH2Li and a molecular weight of 64.06 g/mol. Supplied as a technical grade solution in heptane (~1.7 M), it serves as a strong base and nucleophile in organic synthesis. Its pyrophoric and corrosive nature necessitates expert handling. It is widely employed as a reagent in chemical synthesis, particularly for the formation of carbon-carbon bonds and in polymerisation processes.
- IUPAC
- Lithium 2-methyl-1-propanide
- Synonyms
- Lithium 2-methyl-1-propanide
Strong Base in Organic Synthesis
Isobutyllithium acts as a powerful non-nucleophilic base for deprotonation reactions, enabling the synthesis of complex organic molecules. It is crucial for generating enolates and carbanions for subsequent alkylation or addition reactions.
Organometallic Reagent
As an organometallic compound, it participates in various coupling reactions and serves as a precursor for other organometallic species. Its utility spans the synthesis of pharmaceuticals, agrochemicals, and advanced materials.
Polymerisation Initiator
In anionic polymerisation, isobutyllithium can initiate the formation of polymers, offering control over molecular weight and polymer architecture. This is particularly relevant in the production of synthetic rubbers and elastomers.
| Molecular weight | 64.06 |
|---|---|
| Linear formula | (CH3)2CHCH2Li |
| Grade | technical |
| Density | 0.69 g/mL at 20 °C |
| Concentration | ~16% in heptane (~1.7 M) |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H260In contact with water releases flammable gases
- H304May be fatal if swallowed and enters airways
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P222Do not allow contact with air
- P223Do not allow contact with water
- P231Handle under inert gas
- P370In case of fire
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -4 °C / 24.8 °F |
| Transport (UN / ADR) | UN 3394 4.2/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,C,N |
| Risk statements (R) | 11-14/15-17-34-50/53-65-67 |
| Safety statements (S) | 26-36/37/39-43-45-61-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isobutyllithium solution primarily used for?
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Isobutyllithium solution is primarily used as a strong base and nucleophile in organic synthesis, for the formation of carbon-carbon bonds, and as an initiator in polymerisation.
What are the CAS number and chemical formula for Isobutyllithium solution?
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The CAS number is 920-36-5, and the linear formula is (CH3)2CHCH2Li.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isobutyllithium solution in technical grade, as approximately a 16% solution in heptane (~1.7 M). TSS does not represent this product as USP, BP, or EP grade.
How should Isobutyllithium solution be handled safely?
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Isobutyllithium solution is pyrophoric, flammable, and corrosive. Handle under an inert atmosphere (e.g., nitrogen or argon) in a well-ventilated fume hood, wearing appropriate personal protective equipment including gloves, goggles, and a face shield. Avoid contact with air and moisture.
How is Isobutyllithium solution packed, shipped, and exported?
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Isobutyllithium solution is shipped under UN 3394, Hazard Class 4.2 (Spontaneously Combustible Substances), Packing Group I, requiring specialised packaging and handling. TSS expertly manages its global export.
How can I request a sample or quote for Isobutyllithium solution?
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Please contact our sales team via the website or direct email to request a sample or obtain a quotation for Isobutyllithium solution.
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