Hydroxyfasudil hydrochloride hydrate
Hydroxyfasudil hydrochloride hydrate (CAS: 155558-32-0) is a chemical compound with the molecular formula C14H17N3O3S · HCl · xH2O. It is supplied as a white, solid material. This compound serves as a valuable tool in biochemical research, primarily as an inhibitor of Rho-kinase (ROCK). Its applications are concentrated in cell biology and neuroscience research, aiding investigations into cellular signalling pathways.
- IUPAC
- 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
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Rho-Kinase (ROCK) Inhibition
Hydroxyfasudil hydrochloride hydrate is a potent inhibitor of Rho-kinase (ROCK), a key enzyme involved in cellular processes such as cell contraction, adhesion, and migration. It is widely used in research settings to explore the physiological and pathological roles of ROCK signalling.
Cellular Signalling Studies
This compound is instrumental in studying intracellular signalling cascades, particularly those regulated by Rho GTPases. Researchers utilise it to dissect the downstream effects of ROCK inhibition in various cell types.
Neuroscience Research
Given the involvement of ROCK in neuronal function and development, hydroxyfasudil hydrochloride hydrate finds application in neuroscience research. It can be used to investigate potential therapeutic targets for neurological disorders.
Biochemical and Cell Biology Tool
As a well-characterised biochemical reagent, it aids in fundamental cell biology experiments. Its specific inhibitory action allows for precise manipulation of cellular functions in vitro.
| Molecular weight | 343.83 (anhydrous basis) |
|---|---|
| Empirical formula | C14H17N3O3S · HCl · xH2O |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white |
| Solubility | H2O: >5 mg/mL |
| Storage temperature | 2-8°C |
| Composition | The two peaks show the equilibrim between the two tautomers |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hydroxyfasudil hydrochloride hydrate used for?
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Hydroxyfasudil hydrochloride hydrate is primarily used as a research tool in cell biology, neuroscience, and biochemistry. It acts as an inhibitor of Rho-kinase (ROCK), aiding in the study of cellular signalling pathways, cell contraction, and migration.
What is the CAS number and molecular formula for Hydroxyfasudil hydrochloride hydrate?
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The CAS number for the anhydrous form is 155558-32-0. The molecular formula is C14H17N3O3S · HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Hydroxyfasudil hydrochloride hydrate with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Hydroxyfasudil hydrochloride hydrate be handled safely?
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Hydroxyfasudil hydrochloride hydrate is classified with GHS07 and a Warning signal word, with hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, faceshields, and gloves. Handle in a well-ventilated area.
How is Hydroxyfasudil hydrochloride hydrate packed, shipped, and exported?
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This product is typically supplied as a white solid and stored at 2-8°C. As a global supplier, Tech Serve Solutions ensures compliant packing, shipping, and export of all its chemical products worldwide.
How can I request a quote or sample for Hydroxyfasudil hydrochloride hydrate?
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To request a quote or a sample, please contact our sales team through the website or call us directly. We are happy to assist with your research needs.
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