Hexadecyltrimethoxysilane
Hexadecyltrimethoxysilane (CAS: 16415-12-6), with the molecular formula C19H42O3Si and a molecular weight of 346.62 g/mol, is a versatile organosilicon compound. It functions as a coupling agent and surface modifier, particularly valuable in materials science and micro/nanoelectronics. This silane is employed in chemical synthesis and self-assembly applications, contributing to the development of advanced materials.
- IUPAC
- Trimethoxyhexadecylsilane
- Synonyms
- Trimethoxyhexadecylsilane

Surface Modification
Hexadecyltrimethoxysilane is used to create hydrophobic and chemically functionalised surfaces on various substrates, including glass and metal oxides. This modification enhances material properties for applications in microelectronics and sensor technology.
Self-Assembly
This silane is instrumental in forming ordered molecular monolayers through self-assembly processes. These monolayers are crucial for applications requiring precise control over surface properties, such as in lithography and advanced coatings.
Materials Science
It serves as a precursor in the synthesis of advanced materials and composite systems. Its incorporation can improve interfacial adhesion and impart desired characteristics to polymers and inorganic materials.
Chemical Synthesis
As an organosilicon reagent, Hexadecyltrimethoxysilane participates in various organic synthesis pathways. It is particularly useful for introducing long alkyl chains onto silicon-containing structures.
| Molecular weight | 346.62 |
|---|---|
| Linear formula | H3C(CH2)15Si(OCH3)3 |
| Assay | ≥85% (GC) |
| Grade | Vetec™ reagent grade |
| Density | 0.89 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.44 |
| Impurities tested | isomers |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Flash point | 165 °C / 329 °F |
|---|---|
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hexadecyltrimethoxysilane used for?
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Hexadecyltrimethoxysilane is primarily used for surface modification to create hydrophobic layers, in self-assembly processes for creating ordered monolayers, and as a precursor in materials science and chemical synthesis.
What is the CAS number and chemical formula for Hexadecyltrimethoxysilane?
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The CAS number for Hexadecyltrimethoxysilane is 16415-12-6, and its chemical formula is H3C(CH2)15Si(OCH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Hexadecyltrimethoxysilane in Vetec™ reagent grade with an assay of ≥85% (GC), containing isomers as impurities. This product is not represented as USP, BP, or EP grade.
How should Hexadecyltrimethoxysilane be handled safely?
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Hexadecyltrimethoxysilane may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, avoid breathing vapours, and ensure adequate ventilation. Consult the Safety Data Sheet for detailed guidance.
Is Hexadecyltrimethoxysilane a controlled substance?
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Based on the provided data, there is no indication that Hexadecyltrimethoxysilane is a controlled substance.
How is Hexadecyltrimethoxysilane packed, shipped, and exported?
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Tech Serve Solutions, as a global supplier and exporter, ensures appropriate packaging and compliant shipping procedures for Hexadecyltrimethoxysilane to meet international regulations.
How can I request a sample or quote for Hexadecyltrimethoxysilane?
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To request a sample or quote for Hexadecyltrimethoxysilane, please contact the Tech Serve Solutions sales team through the provided channels on our website.
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