GW3965 hydrochloride
GW3965 hydrochloride (CAS: 405911-17-3) is a PPAR and RXR regulator with a molecular weight of 618.51 g/mol and the empirical formula C33H31F3ClNO3 · HCl. This white powder, assaying ≥98% by HPLC, is a valuable tool in cell biology and neuroscience research. It is utilised for its ability to modulate gene expression and cellular signalling pathways, making it significant in studies related to metabolic and inflammatory diseases.
- IUPAC
- 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

PPAR and RXR Receptor Modulation
GW3965 hydrochloride acts as a selective agonist for peroxisome proliferator-activated receptors (PPARs) and retinoid X receptors (RXRs). This makes it a critical reagent for studying their roles in gene regulation and metabolic processes.
Cellular Signalling and Neuroscience Research
This compound is employed in research settings to investigate cellular signalling pathways and their implications in neuroscience. Its effects on gene expression and cellular responses provide insights into various biological functions.
Drug Discovery and Development
As an approved therapeutic/drug candidate, GW3965 hydrochloride serves as a valuable tool in drug discovery. Researchers utilise it to explore potential therapeutic strategies targeting metabolic disorders and inflammatory conditions.
| Molecular weight | 618.51 |
|---|---|
| Empirical formula | C33H31F3ClNO3 · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | DMSO: ≥20 mg/mL |


Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is GW3965 hydrochloride used for?
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GW3965 hydrochloride is used as a PPAR and RXR regulator in research for studying cellular signalling, gene regulation, and as a potential therapeutic agent in areas like metabolic and inflammatory diseases.
What are the CAS number and formula for GW3965 hydrochloride?
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The CAS number for GW3965 hydrochloride is 405911-17-3, and its empirical formula is C33H31F3ClNO3 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies GW3965 hydrochloride with a purity of ≥98% determined by HPLC. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for GW3965 hydrochloride?
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GW3965 hydrochloride is labelled with GHS05 and GHS07 symbols, with a Danger signal word, indicating hazards such as H302 (Harmful if swallowed) and H318 (Causes serious eye damage), and H413 (May cause long lasting harmful effects to aquatic life). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn during handling. It is classified with WGK 2 in Germany.
How is GW3965 hydrochloride packed, shipped, and exported?
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GW3965 hydrochloride is typically supplied as a white powder and is carefully packaged for secure shipment and export worldwide in compliance with relevant regulations.
How can I request a sample or quote for GW3965 hydrochloride?
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To request a sample or a quotation for GW3965 hydrochloride, please contact our sales department through the website or via email, providing your contact details and the quantity required.
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