Guanosine 5′-[γ-thio]triphosphate tetralithium salt
Guanosine 5′-[γ-thio]triphosphate tetralithium salt (CAS 94825-44-2), with the empirical formula C10H12Li4N5O13P3S and a molecular weight of 562.98, is a thio-analogue of GTP. This white to off-white powder is a crucial reagent in biochemical research, particularly for studying G protein activation and related cellular signalling pathways. Its applications span cell biology and neuroscience, aiding in the understanding of complex biological mechanisms.
- IUPAC
- GTPγS tetralithium salt,GTP-γ-S-Li4,Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt
- Synonyms
- GTPγS tetralithium saltGTP-γ-S-Li4Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt
![Guanosine 5′-[γ-thio]triphosphate tetralithium salt (C10H12Li4N5O13P3S) — chemical structure, CAS 94825-44-2; Life Science, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F94825-44-2.png&w=3840&q=75)
G Protein Research
Guanosine 5′-[γ-thio]triphosphate tetralithium salt is widely employed to activate G proteins in vitro. This allows researchers to investigate the molecular mechanisms of signal transduction pathways regulated by G proteins.
Enzyme Activity Studies
The compound serves as a substrate analogue for enzymes that utilise GTP, enabling the study of enzyme kinetics and mechanisms, particularly those involved in nucleotide metabolism and signalling.
Cellular Signalling Investigations
Its use is pivotal in cell biology and neuroscience research to probe signal transduction pathways, including those mediated by cyclic nucleotides and other second messengers.
| Molecular weight | 562.98 |
|---|---|
| Empirical formula | C10H12Li4N5O13P3S |
| Assay | ≥75% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.) |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | dry ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Guanosine 5′-[γ-thio]triphosphate tetralithium salt used for?
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Guanosine 5′-[γ-thio]triphosphate tetralithium salt is primarily used in biochemical research for studying G protein activation, enzyme kinetics, and cellular signal transduction pathways, particularly in cell biology and neuroscience.
What is the CAS number and molecular formula?
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The CAS number is 94825-44-2 and the molecular formula is C10H12Li4N5O13P3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Guanosine 5′-[γ-thio]triphosphate tetralithium salt with an assay of ≥75% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Guanosine 5′-[γ-thio]triphosphate tetralithium salt be handled?
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Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Avoid inhalation of dust and ensure adequate ventilation. It is classified as a Warning for skin, eye, and respiratory irritation (H315, H319, H335).
How is this chemical shipped?
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Guanosine 5′-[γ-thio]triphosphate tetralithium salt is shipped on dry ice.
How can I request a sample or quote?
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Please contact Tech Serve Solutions directly via our website or phone to request a sample or obtain a quotation for Guanosine 5′-[γ-thio]triphosphate tetralithium salt.
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