Granisetron hydrochloride
Granisetron hydrochloride (CAS: 107007-99-8; Formula: C18H24N4O · HCl; MW: 348.87) is a white to off-white solid compound. It functions as a selective serotonin 5-HT3 receptor antagonist. This bioactive small molecule is primarily recognised for its therapeutic applications in managing nausea and vomiting, particularly those induced by chemotherapy and radiotherapy, and in the post-operative setting.
- IUPAC
- 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Chemotherapy-Induced Nausea and Vomiting (CINV)
Granisetron hydrochloride is widely utilised to prevent and treat nausea and vomiting experienced by patients undergoing cancer chemotherapy. Its selective antagonism of 5-HT3 receptors helps to mitigate these common side effects.
Radiotherapy-Induced Nausea and Vomiting (RINV)
Similar to its use in chemotherapy, granisetron hydrochloride is effective in managing nausea and vomiting associated with radiation therapy. It provides symptomatic relief by blocking serotonin's action in the chemoreceptor trigger zone.
Post-Operative Nausea and Vomiting (PONV)
This compound is also indicated for the prevention and treatment of nausea and vomiting that can occur after surgical procedures. Its antiemetic properties contribute to patient comfort and recovery.
| Molecular weight | 348.87 |
|---|---|
| Empirical formula | C18H24N4O · HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | H2O: >10 mg/mL |
| Storage temperature | room temp |
| Melting point | 284.0-290.0 °C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Granisetron hydrochloride used for?
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Granisetron hydrochloride is used to prevent and treat nausea and vomiting, commonly associated with chemotherapy, radiotherapy, and post-operative recovery.
What are the CAS number and formula for Granisetron hydrochloride?
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The CAS number for Granisetron hydrochloride is 107007-99-8, and its molecular formula is C18H24N4O · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Granisetron hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Granisetron hydrochloride be handled safely?
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Granisetron hydrochloride is classified with GHS07 and a Warning signal word, with hazard statement H302 (Harmful if swallowed). When handling, use a dust mask type N95 (US), eyeshields, faceshields, and gloves. Ensure adequate ventilation and avoid ingestion.
Is Granisetron hydrochloride a controlled substance?
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The provided data does not indicate that Granisetron hydrochloride is a controlled substance. However, users should verify local regulations.
How is Granisetron hydrochloride packed and shipped?
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Granisetron hydrochloride is typically shipped at room temperature. Please contact our sales team for specific packaging and export details.
How can I request a quote or sample of Granisetron hydrochloride?
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To request a quote or sample, please contact the Tech Serve Solutions sales department via our website or direct inquiry.
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