Gramicidin A from Bacillus brevis
Gramicidin A from Bacillus brevis (CAS: 11029-61-1) is a linear pentadecapeptide antibiotic. It functions by interfering with bacterial cell membrane permeability, acting as a monovalent cation channel. This compound is valuable in research for studying bacterial cell wall permeabilization and is also employed in investigations into ionophore activity and various biological processes, including its inhibitory effects on transcription and enzyme activity.
Antibacterial Research
Gramicidin A is used in laboratory settings to study its effects on bacterial cell walls and membranes, specifically its role in permeabilization and monovalent cation channel formation.
Biochemical Studies
This peptide is utilised for investigating its inhibitory effects on enzymes, such as membrane-bound epidennal adenosine triphosphatase, and its influence on cellular processes like transcription.
Immunological Research
Gramicidin A has been studied for its impact on human lymphocyte blastogenesis in vitro, providing insights into immune cell responses.
Transplantation Research
In preclinical models, Gramicidin A has demonstrated the ability to prolong heart allograft survival in rats, suggesting potential applications in transplant research.
| Assay | ≥90% (HPLC) |
|---|---|
| Storage temperature | 2-8°C |
| Impurities tested | ≤5% gramicidin C≤5% water |
| Application | Gramicidin A is a linear pentadecapeptide antibiotic which is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model 1,2,3. |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Gramicidin A from Bacillus brevis used for?
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Gramicidin A from Bacillus brevis is used for studies on bacterial cell wall permeabilization, monovalent cation channel formation, and investigations into its inhibitory effects on transcription and enzymes.
What are the CAS number and chemical formula for Gramicidin A?
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The CAS number for Gramicidin A from Bacillus brevis is 11029-61-1. The chemical formula is not provided in the data.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Gramicidin A with an assay of ≥90% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Gramicidin A be handled safely?
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Gramicidin A is classified as harmful if swallowed (H302). When handling, use a dust mask type N95 (US), eyeshields, and gloves.
Is Gramicidin A suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Gramicidin A from Bacillus brevis.
How can I request a quote or sample for Gramicidin A?
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To request a quote or sample for Gramicidin A, please contact our sales team through the website or by phone.
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