Fmoc-D-Arg(Pbf)-OH
Fmoc-D-Arg(Pbf)-OH (CAS: 187618-60-6) is a protected D-arginine derivative with the molecular formula C34H40N4O7S and a molecular weight of 648.77 g/mol. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS). Its structure features the Fmoc protecting group on the alpha-amino group and the Pbf protecting group on the guanidino moiety, facilitating controlled peptide chain elongation and ensuring selective deprotection strategies. It is widely used in research and development settings for the synthesis of peptides and peptidomimetics.
- IUPAC
- Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine,Nα-Fmoc-Nω-Pbf-D-arginine
- Synonyms
- Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginineNα-Fmoc-Nω-Pbf-D-arginine
Peptide Synthesis
Fmoc-D-Arg(Pbf)-OH is a key component in the Fmoc-based solid-phase peptide synthesis (SPPS) strategy. It allows for the incorporation of D-arginine into peptide sequences, which can confer unique biological properties or increased resistance to enzymatic degradation.
Drug Discovery and Development
This protected amino acid derivative is utilized in the research of novel peptide-based therapeutics. Its specific stereochemistry and protecting groups are essential for creating complex peptide structures with potential pharmaceutical applications.
Chemical Biology Research
Researchers employ Fmoc-D-Arg(Pbf)-OH to construct peptides for studying protein-protein interactions, enzyme substrates, and other biological processes. The Pbf protecting group offers robust protection during synthesis, with straightforward removal conditions.
Analytical Standard Development
As a well-defined chemical entity, it can be used in the development and validation of analytical methods for peptide quantification and characterisation, particularly within chromatography and mass spectrometry.
| Molecular weight | 648.77 |
|---|---|
| Empirical formula | C34H40N4O7S |
| Assay | ≥98.0% (TLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Arg(Pbf)-OH primarily used for?
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Fmoc-D-Arg(Pbf)-OH is primarily used as a protected building block in solid-phase peptide synthesis (SPPS), especially in the Fmoc strategy, for incorporating D-arginine into peptide chains during research and drug discovery.
What are the CAS number and molecular formula for Fmoc-D-Arg(Pbf)-OH?
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The CAS number for Fmoc-D-Arg(Pbf)-OH is 187618-60-6, and its molecular formula is C34H40N4O7S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-Arg(Pbf)-OH with a purity of ≥98.0% (TLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Fmoc-D-Arg(Pbf)-OH be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or P1 (EN143) respirator filter is recommended. The compound should be stored at refrigerated temperatures between 2-8°C.
Is this chemical a controlled substance?
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The provided data does not indicate that Fmoc-D-Arg(Pbf)-OH is a controlled substance.
How can I request a quote or sample for Fmoc-D-Arg(Pbf)-OH?
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To request a quote or sample, please contact our sales department via the website or directly by phone. Our team will be pleased to assist you with your specific requirements.
How is Fmoc-D-Arg(Pbf)-OH packed and exported?
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Fmoc-D-Arg(Pbf)-OH is carefully packed according to industry standards to ensure stability during transport and is available for global export by Tech Serve Solutions.
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