Ethyl trimethylsilylacetate
Ethyl trimethylsilylacetate (CAS 4071-88-9) is a chemical compound with the linear formula (CH3)3SiCH2CO2C2H5 and a molecular weight of 160.29 g/mol. This ester serves as a versatile building block in organic synthesis. It is primarily utilised in chemical manufacturing processes where the introduction of a protected acetate moiety is required, functioning as a useful reagent in various synthetic transformations.
- IUPAC
- ETSA

Organic Synthesis Reagent
Ethyl trimethylsilylacetate acts as a valuable reagent in organic chemistry. Its silyl group offers a convenient way to introduce an acetate functional group, which can be further manipulated in complex synthetic routes.
Pharmaceutical Intermediate
This compound may be employed in the synthesis of pharmaceutical intermediates. Its specific reactivity allows for the construction of carbon frameworks essential for the development of active pharmaceutical ingredients.
Building Block for Fine Chemicals
As a building block, ethyl trimethylsilylacetate contributes to the creation of various fine chemicals. It is incorporated into multi-step syntheses requiring precise control over functional group transformations.
| Molecular weight | 160.29 |
|---|---|
| Linear formula | (CH3)3SiCH2CO2C2H5 |
| Assay | 99% |
| Grade | purum |
| Boiling point | 156-159 °C(lit.) |
| Density | 0.876 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.415(lit.) |

Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 48 °C / 118.4 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl trimethylsilylacetate used for?
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Ethyl trimethylsilylacetate is used as a building block and reagent in organic synthesis, particularly for introducing acetate moieties in the preparation of fine chemicals and pharmaceutical intermediates.
What are the CAS number and formula for Ethyl trimethylsilylacetate?
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The CAS number for Ethyl trimethylsilylacetate is 4071-88-9, and its linear formula is (CH3)3SiCH2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl trimethylsilylacetate in a 'purum' grade with an assay of 99%. This product is intended for laboratory and chemical synthesis use and is not represented as USP, BP, or EP grade.
What are the safety considerations for Ethyl trimethylsilylacetate?
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Ethyl trimethylsilylacetate is a flammable liquid (H226) and requires appropriate handling. It necessitates the use of safety measures such as eyeshields, gloves, and suitable respiratory protection. Always consult the Safety Data Sheet (SDS) before use.
How is Ethyl trimethylsilylacetate packed and shipped?
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Ethyl trimethylsilylacetate is packed and shipped according to relevant transport regulations (UN 3272 3 / PGIII). As a global supplier and exporter, Tech Serve Solutions ensures compliance with international shipping standards for chemical products.
How can I request a sample or quote for Ethyl trimethylsilylacetate?
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To request a sample or a quote for Ethyl trimethylsilylacetate, please contact the Tech Serve Solutions sales team via the website or your designated sales representative.
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