Ethyl trifluoroacetate
Ethyl trifluoroacetate (CAS: 383-63-1), with the linear formula CF<sub>3</sub>COOC<sub>2</sub>H<sub>5</sub> and a molecular weight of 142.08 g/mol, is a vital organic building block. This ester, characterised by its trifluoromethyl group, serves as a key intermediate in organic synthesis. It is frequently employed in the creation of various complex molecules within the pharmaceutical and agrochemical industries, owing to its specific reactivity and the valuable trifluoromethyl moiety it introduces.
- IUPAC
- Trifluoroacetic acid ethyl ester
- Synonyms
- Trifluoroacetic acid ethyl esterEthyl fluoroformate2,2,2-Trifluoroethyl trifluoroacetate
Fluorinated Compound Synthesis
Ethyl trifluoroacetate is a valuable reagent for introducing the trifluoromethyl group into organic molecules. This is crucial for modifying the properties of pharmaceuticals and agrochemicals, often enhancing their efficacy and stability.
Pharmaceutical Intermediates
It serves as a building block in the synthesis of active pharmaceutical ingredients (APIs). The incorporation of fluorine can significantly impact a drug's metabolic stability, lipophilicity, and binding affinity.
Agrochemical Development
This ester is used in the development of new pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental persistence characteristics.
Organic Synthesis Reagent
As a versatile ester, it participates in various organic reactions, including ester condensations and acylations, providing a reactive source of the trifluoroacetyl group for complex molecule construction.
| Molecular weight | 142.08 |
|---|---|
| Linear formula | CF3COOC2H5 |
| Assay | 99% |
| Boiling point | 60-62 °C(lit.) |
| Density | 1.194 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.307(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -1 °C / 30.2 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-22-37/38-41 |
| Safety statements (S) | 9-16-26-36/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl trifluoroacetate used for?
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Ethyl trifluoroacetate is primarily used as a building block in organic synthesis, particularly for introducing the trifluoromethyl group into pharmaceuticals, agrochemicals, and other complex organic molecules.
What are the CAS number and formula for Ethyl trifluoroacetate?
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The CAS number for Ethyl trifluoroacetate is 383-63-1, and its linear formula is CF3COOC2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl trifluoroacetate with an assay of 99%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated otherwise.
How should Ethyl trifluoroacetate be handled safely?
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Ethyl trifluoroacetate is a flammable liquid and vapour (H225), harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eye protection, gloves, and ensure adequate ventilation. Store away from ignition sources.
How is Ethyl trifluoroacetate packed, shipped, and exported?
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Ethyl trifluoroacetate is available in various pack sizes suitable for laboratory and industrial use. As a global supplier, Tech Serve Solutions adheres to all relevant shipping regulations for hazardous materials, including UN 1993 BF 3 / PGII classification, for export.
How can I request a quote or sample for Ethyl trifluoroacetate?
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To request a quote or a sample of Ethyl trifluoroacetate, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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