Ethyl dichlorothiophosphate
Ethyl dichlorothiophosphate (CAS: 1498-64-2; Formula: C2H5OP(S)Cl2; MW: 179.01) is a versatile organophosphorus compound. It functions as a key intermediate and phosphorylating agent in organic synthesis. Utilised in the chemical industry for the production of various phosphorus-containing compounds, it serves as a critical building block in complex molecular architectures.
- IUPAC
- Ethyl phosphorodichloridothionate

Organic Synthesis Intermediate
Ethyl dichlorothiophosphate is employed as a fundamental building block in the synthesis of diverse organic molecules. Its reactive chlorine atoms allow for facile derivatisation in the creation of more complex organophosphorus compounds.
Phosphorylating Agent
This compound acts as an effective phosphorylating agent, introducing the thiophosphoryl group into organic substrates. This reactivity is essential in the development of novel chemical entities within research and industrial settings.
Precursor for Agrochemicals and Pharmaceuticals
It serves as a precursor in the multi-step synthesis pathways for certain agrochemicals and pharmaceutical intermediates. Its incorporation allows for the precise introduction of phosphorus functionalities.
| Molecular weight | 179.01 |
|---|---|
| Linear formula | C2H5OP(S)Cl2 |
| Assay | 95% |
| Boiling point | 55-68 °C/10 mmHg(lit.) |
| Density | 1.353 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.504(lit.) |
| Vapour pressure | 10 mmHg (55 °C) |


Hazard statements
- H302Harmful if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3390 6.1/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 22-23/24-34 |
| Safety statements (S) | 22-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl dichlorothiophosphate used for?
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Ethyl dichlorothiophosphate is primarily used as an intermediate in organic synthesis and as a phosphorylating agent for creating various phosphorus-containing compounds. It also serves as a precursor in the synthesis of agrochemicals and pharmaceutical intermediates.
What is the CAS number and chemical formula for Ethyl dichlorothiophosphate?
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The CAS number is 1498-64-2, and the chemical formula is C2H5OP(S)Cl2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl dichlorothiophosphate with a minimum assay of 95%. This is considered a technical grade suitable for research and synthesis, and is not represented as USP, BP, or EP grade.
How should Ethyl dichlorothiophosphate be handled safely?
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Ethyl dichlorothiophosphate is a hazardous substance and must be handled with extreme care. It causes severe skin burns and eye damage, is harmful if swallowed, and is toxic if inhaled or in contact with skin. Always use appropriate personal protective equipment, including chemical-resistant gloves, eye protection (face shield and goggles), and respiratory protection, in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for detailed handling procedures.
How is Ethyl dichlorothiophosphate packed, shipped, and exported?
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Ethyl dichlorothiophosphate is packed in accordance with international transport regulations for hazardous materials. As a global supplier, Tech Serve Solutions exports this chemical, ensuring compliance with all relevant shipping and customs requirements.
How can I request a quote or sample for Ethyl dichlorothiophosphate?
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To request a quote or a sample of Ethyl dichlorothiophosphate, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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