Ethyl chloroformate
Ethyl chloroformate (CAS 541-41-3), molecular formula ClCOOC2H5, is a high-purity chemical supplied by Tech Serve Solutions for chemical synthesis applications, to pharmacopoeia specification (USP, BP, EP). Every batch is tested and ships with a Certificate of Analysis; MSDS and technical data sheets are available on request. Tech Serve Solutions has supplied laboratory reagents, fine chemicals and pharmaceutical intermediates worldwide since 1998.
- IUPAC
- Chloroformic acid ethyl ester

| Molecular weight | 108.52 |
|---|---|
| Linear formula | ClCOOC2H5 |
| Assay | 97% |
| Boiling point | 93 °C(lit.) |
| Density | 1.135 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.395(lit.) |
| Solubility | alcohol: misciblebenzene: misciblechloroform: misciblediethyl ether: misciblewater: insoluble |
| Melting point | −81 °C(lit.) |
| Vapour pressure | 3.42 psi (20 °C) |
| Vapour density | 3.74 (vs air) |
| Autoignition temp | 842 °F |
| Application | • Ethyl chloroformate was used in the synthesis of nitrile oxides1. • It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction2. • It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography3.• It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography4. • It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles5. |



Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 10 °C / 50 °F |
| Transport (UN / ADR) | UN 1182 6.1/PG 1 |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,T+ |
| Risk statements (R) | 11-22-26-34 |
| Safety statements (S) | 9-16-26-28-33-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Supplied to USP, BP and EP standards. Every batch ships with a Certificate of Analysis (assay, identity, purity); MSDS and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl chloroformate?
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Ethyl chloroformate (CAS 541-41-3), molecular formula ClCOOC2H5, is a high-purity chemical supplied by Tech Serve Solutions for chemical synthesis applications, to USP, BP and EP standards.
What grades of Ethyl chloroformate does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl chloroformate in USP, BP, EP and reagent/AR grades. Custom specifications for nutraceutical or specialty pharmaceutical applications are available — contact our technical sales team.
What is the CAS number and molecular formula of Ethyl chloroformate?
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Ethyl chloroformate has CAS number 541-41-3 and molecular formula ClCOOC2H5. Full specifications appear in the table above and in the Certificate of Analysis.
What is the typical minimum order quantity and lead time for Ethyl chloroformate?
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Sample quantities are available for technical evaluation; bulk MOQ depends on grade and packaging. In-stock material typically ships in 7–10 working days; custom-spec orders take 3–4 weeks. Tech Serve Solutions ships worldwide with full export documentation.
Do you provide a Certificate of Analysis (CoA) with each shipment?
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Yes. Every batch of Ethyl chloroformate ships with a Certificate of Analysis covering assay, identity and purity tests, plus pharmacopoeia conformance where applicable. MSDS and TDS documents are available on request before order placement.
How should Ethyl chloroformate be stored?
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Store Ethyl chloroformate in its original sealed container in a cool, dry place away from direct sunlight and incompatible materials, in line with the storage guidance on the Safety Data Sheet. Reseal between dispensings.
What is Ethyl chloroformate used for?
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Ethyl chloroformate is used in chemical synthesis applications across pharmaceutical, research and industrial settings. Our technical team can advise on suitability for your specific process.
How do I request a quote for Ethyl chloroformate?
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Request a quote with your required grade, quantity and destination via https://www.techservesolutions.in/contact or email info@techservesolutions.in. We respond with specifications, a Certificate of Analysis and pricing.
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