Ethyl chloroacetate
Ethyl chloroacetate (CAS 105-39-5) is a clear, colourless liquid with the molecular formula C4H7ClO2 and a molecular weight of 122.55 g/mol. This ester is a valuable organic intermediate, frequently employed in the synthesis of pharmaceuticals, agrochemicals, and other complex organic molecules. Its reactivity makes it a versatile building block for introducing the chloroacetyl group in various chemical transformations.
Pharmaceutical Synthesis
Ethyl chloroacetate serves as a key intermediate in the production of various active pharmaceutical ingredients (APIs). It is utilised in reactions that require the introduction of an ester and a reactive chlorine atom, facilitating the construction of complex drug molecules.
Agrochemical Intermediates
This compound is used in the synthesis of certain pesticides and herbicides. Its structure allows for its incorporation into molecules designed to protect crops and enhance agricultural yields.
Organic Synthesis Building Block
As a versatile C2 to C5 building block, ethyl chloroacetate is employed in a wide range of organic synthetic procedures. It is particularly useful for alkylation reactions and the formation of carbon-carbon bonds.
Dye and Pigment Production
Ethyl chloroacetate can be a precursor in the manufacturing of specific dyes and pigments, contributing to the colourant industry.
| Molecular weight | 122.55 |
|---|---|
| Linear formula | ClCH2CO2C2H5 |
| Assay | ≥98.0% (GC) |
| Boiling point | 143 °C(lit.) |
| Density | 1.145 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.421(lit.)n20/D 1.422 |
| Vapour pressure | 10 mmHg (38 °C)3.3 mmHg (20 °C) |
| Melting point | −26 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H318Causes serious eye damage
- H331Toxic if inhaled
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 54 °C / 129.2 °F |
| Transport (UN / ADR) | UN 1181 6.1/PG 2 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 23/24/25-50 |
| Safety statements (S) | 7/9-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Transition Temp | solidification point ~−26 °C |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl chloroacetate used for?
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Ethyl chloroacetate is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, dyes, and as a general building block in organic chemistry.
What are the CAS number and chemical formula for Ethyl chloroacetate?
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The CAS number for Ethyl chloroacetate is 105-39-5, and its linear formula is ClCH₂CO₂C₂H₅.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl chloroacetate with a purity of ≥98.0% (GC). We do not represent this product as USP, BP, or EP grade.
How should Ethyl chloroacetate be handled safely?
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Ethyl chloroacetate is a dangerous substance. It is flammable, toxic if swallowed, in contact with skin, or inhaled, and causes serious eye damage. Handle only with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling information.
How is Ethyl chloroacetate packed and exported?
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Ethyl chloroacetate is packed according to international shipping regulations for hazardous materials and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for Ethyl chloroacetate?
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To request a sample or a quote for Ethyl chloroacetate, please use the enquiry form on our website or contact our sales team directly.
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