Ethyl chlorodifluoroacetate
Ethyl chlorodifluoroacetate (CAS: 383-62-0) is a fluorinated ester with the linear formula ClCF2CO2C2H5 and a molecular weight of 158.53 g/mol. This compound serves as a valuable building block in organic synthesis, particularly within the realm of fluorinated organic chemistry. Its structure lends itself to various chemical transformations, making it a useful intermediate for creating more complex fluorinated molecules.

Fluorinated Organic Synthesis
Ethyl chlorodifluoroacetate is employed as a key intermediate in the synthesis of diverse fluorinated organic compounds. Its reactive chlorodifluoroacetyl group can be incorporated into various molecular frameworks.
Pharmaceutical Intermediates
This chemical finds application in the development of novel pharmaceutical agents. The introduction of fluorine atoms can significantly influence the pharmacokinetic and pharmacodynamic properties of drug candidates.
Material Science
As a fluorinated building block, it can be utilised in the creation of specialised polymers and materials where the unique properties conferred by fluorine are desired, such as enhanced thermal stability or chemical resistance.
| Molecular weight | 158.53 |
|---|---|
| Linear formula | ClCF2CO2C2H5 |
| Assay | 98% |
| Boiling point | 96-97.5 °C(lit.) |
| Density | 1.252 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.358(lit.) |


Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 18 °C / 64.4 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl chlorodifluoroacetate used for?
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Ethyl chlorodifluoroacetate is primarily used as a building block in organic synthesis, particularly for the preparation of fluorinated organic compounds, pharmaceutical intermediates, and in material science applications.
What is the CAS number and formula for Ethyl chlorodifluoroacetate?
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The CAS number is 383-62-0 and the linear formula is ClCF2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl chlorodifluoroacetate with a purity of 98% assay. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product documentation.
How should Ethyl chlorodifluoroacetate be handled safely?
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Ethyl chlorodifluoroacetate is a hazardous substance. It is flammable (H225) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including gloves, goggles, faceshields, and a suitable respirator, must be worn. Handle in a well-ventilated area, away from ignition sources.
Is Ethyl chlorodifluoroacetate a controlled substance?
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Based on the provided data, there is no indication that Ethyl chlorodifluoroacetate (CAS: 383-62-0) is a controlled substance.
How is Ethyl chlorodifluoroacetate packed, shipped, and exported?
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Ethyl chlorodifluoroacetate is packed in compliance with international shipping regulations for hazardous materials, including UN 2924, Class 8(3), Packing Group II. TSS exports globally, adhering to all relevant regulations.
How can I request a sample or quote for Ethyl chlorodifluoroacetate?
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To request a sample or a quotation for Ethyl chlorodifluoroacetate, please contact our sales team through the website or by phone, referencing the product name and CAS number (383-62-0).
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