Ethyl bromodifluoroacetate
Ethyl bromodifluoroacetate (CAS: 667-27-6) is a fluorinated organic building block with the linear formula BrCF2COOCH2CH3 and a molecular weight of 202.98 g/mol. This ester is valued in organic synthesis for introducing difluoromethylene ester functionalities. It is primarily employed in the preparation of various complex organic molecules, including heterocyclic compounds and difluorinated intermediates, serving as a versatile reagent in medicinal chemistry and materials science research.
Synthesis of Substituted Pyridines
Ethyl bromodifluoroacetate serves as a key reagent in the preparation of substituted ethyl 2'-pyridyldifluoroacetates. This application highlights its utility in constructing complex heterocyclic systems.
Preparation of Difluoropiperidines
The compound is utilised in the synthesis of 4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines. These difluorinated cyclic structures are of interest in pharmaceutical research and development.
Construction of Difluoro-β-lactams
Ethyl bromodifluoroacetate facilitates the synthesis of α,α-difluoro-β-lactams. These strained ring systems are important intermediates in organic synthesis and can be precursors to various biologically active molecules.
Formation of Difluoromethylated Heterocycles
This reagent is employed in the preparation of mono- and difluoromethylated phenanthridine derivatives, demonstrating its role in introducing specific fluorinated motifs into polycyclic aromatic systems.
| Molecular weight | 202.98 |
|---|---|
| Linear formula | BrCF2COOCH2CH3 |
| Assay | 98% |
| Boiling point | 112 °C/700 mmHg(lit.) |
| Density | 1.583 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.387(lit.) |
| Application | Ethyl bromodifluoroacetate has been used in the preparation of:• substituted ethyl 2′-pyridyldifluoroacetates1• 4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines2• α,α-difluoro-β-lactams3• mono- and difluoromethylated phenanthridine derivatives4 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 21 °C / 69.8 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl bromodifluoroacetate used for?
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Ethyl bromodifluoroacetate is used as a building block in organic synthesis, particularly for introducing difluoromethylene ester groups into molecules. It has applications in the preparation of substituted pyridines, difluoropiperidines, α,α-difluoro-β-lactams, and difluoromethylated phenanthridine derivatives.
What is the CAS number and formula for Ethyl bromodifluoroacetate?
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The CAS number for Ethyl bromodifluoroacetate is 667-27-6. Its linear formula is BrCF2COOCH2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl bromodifluoroacetate with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Ethyl bromodifluoroacetate be handled safely?
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Ethyl bromodifluoroacetate is classified as a dangerous substance. It is highly flammable and causes severe skin burns and eye damage. Always handle with appropriate personal protective equipment, including gloves, goggles, face shield, and a suitable respirator. Ensure adequate ventilation and avoid ignition sources. Refer to the Safety Data Sheet for detailed handling and emergency procedures.
How is Ethyl bromodifluoroacetate packed, shipped, and exported?
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Ethyl bromodifluoroacetate is packed according to international shipping regulations for hazardous materials. As a global supplier, TSS exports this chemical worldwide, adhering to all relevant transport and customs requirements.
How can I request a sample or a quote for Ethyl bromodifluoroacetate?
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To request a sample or a quote for Ethyl bromodifluoroacetate, please contact our sales team via the website or by calling our customer service number. Please provide your contact details and the quantity required.
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