Ethyl bromoacetate
Ethyl bromoacetate (CAS: 105-36-2), with the linear formula BrCH₂COOC₂H₅ and a molecular weight of 167.00 g/mol, is a key organic building block. This ester is frequently employed in organic synthesis for the introduction of the bromoacetyl group. Its reactivity makes it a valuable intermediate in the preparation of diverse chemical compounds, including pharmaceuticals and complex organic molecules.
Pharmaceutical Intermediate Synthesis
Ethyl bromoacetate is utilised in the synthesis of various pharmaceutical intermediates, such as artificial diethylstilbestrol antigen and novel pyrazolothiazol-4(5H)-ones. Its role as a building block is crucial in constructing complex molecular scaffolds.
Organic Synthesis Reagent
This compound serves as a versatile reagent in organic chemistry. It is employed in the preparation of specific molecules like 3-phenyl-1-naphthol, a key intermediate for compounds such as vanol, and various steroidal thiazolidinone derivatives.
Chemical Research and Development
In research settings, Ethyl bromoacetate facilitates the exploration of new synthetic pathways and the creation of novel chemical entities. Its predictable reactivity supports a wide range of chemical transformations.
| Molecular weight | 167.00 |
|---|---|
| Linear formula | BrCH2COOC2H5 |
| Assay | ≥97.0% (GC) |
| Grade | purum |
| Boiling point | 159 °C(lit.) |
| Density | 1.506 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.451(lit.)n20/D 1.451 |
| Solubility | water: insoluble |
| Vapour pressure | 2.6 mmHg (25 °C) |
| Application | Ethyl bromoacetate was used in the synthesis of:• artificial diethylstilbestrol antigen1• 3-phenyl-1-naphthol, a key intermediate in the synthesis of vanol2• novel pyrazolothiazol-4(5H)-ones3• steroidal thiazolidinone derivatives4 |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 47 °C / 116.6 °F |
| Transport (UN / ADR) | UN 1603 3(6.1) |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 7/9-26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl bromoacetate used for?
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Ethyl bromoacetate is primarily used as a building block in organic synthesis for introducing the bromoacetyl group. It is instrumental in the preparation of pharmaceutical intermediates, such as artificial diethylstilbestrol antigen, 3-phenyl-1-naphthol, novel pyrazolothiazol-4(5H)-ones, and steroidal thiazolidinone derivatives.
What are the CAS number and formula for Ethyl bromoacetate?
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The CAS number for Ethyl bromoacetate is 105-36-2, and its linear formula is BrCH₂COOC₂H₅.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl bromoacetate with a purity of ≥97.0% (GC), designated as 'purum' grade. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the specifications.
How should Ethyl bromoacetate be handled safely?
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Ethyl bromoacetate is a hazardous substance requiring careful handling. It is classified as acutely toxic by inhalation, in contact with skin, and if swallowed (H330, H310, H300). Always use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
Does Tech Serve Solutions export Ethyl bromoacetate?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Ethyl bromoacetate, serving customers worldwide.
How can I request a quote or sample for Ethyl bromoacetate?
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To request a quote or sample for Ethyl bromoacetate, please contact our sales department via the website or by telephone, providing your specific requirements and shipping details.
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