E-64c

CAS 76684-89-4C15H26N2O5Biochemicals & Reagents

E-64c (CAS 76684-89-4), with the molecular formula C15H26N2O5 and a molecular weight of 314.38 g/mol, is a specific epoxide derivative. It is recognised for its role as a potent inhibitor, particularly of cysteine proteases like calpains. This compound is a valuable tool in biochemical research for studying cellular processes regulated by these enzymes, including apoptosis and cell signalling pathways.

IUPAC: (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane

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E-64c (C15H26N2O5) — chemical structure, CAS 76684-89-4; Life Science, fine chemical supplied by Tech Serve Solutions

A to CApoptosis EnzymesApplication IndexBioactive Small MoleculesBiochemicals and ReagentsCalpainCalpain IICalpain II InhibitorsCell BiologyCell Signaling Enzymes

01 /Applications

Calpain Inhibition

E-64c is widely used as a selective inhibitor of calpain proteases, including Calpain I and Calpain II. Its application is crucial for investigating the physiological and pathological roles of calpains in cellular functions such as muscle contraction, cell migration, and apoptosis.

Apoptosis Research

As a modulator of calpain activity, E-64c is employed in studies of programmed cell death (apoptosis). By inhibiting calpain-mediated proteolysis, researchers can elucidate the specific contribution of these enzymes to the apoptotic cascade.

Cell Signalling Studies

The compound serves as a biochemical probe to dissect cell signalling pathways where calpains play a regulatory role. Understanding these pathways is essential for developing therapeutic strategies for various diseases.

02 /Properties

Molecular weight	314.38
Empirical formula	C15H26N2O5
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

76684-89-4

MDL number

MFCD00132882

PubChem substance

24894369

05 /Additional specifications

Gene Information	human ... CAPN1(823)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is E-64c used for?

E-64c is primarily used as a selective inhibitor of calpain proteases, playing a key role in research involving apoptosis, cell signalling, and various cellular processes regulated by cysteine proteases.

What is the CAS number and molecular formula for E-64c?

The CAS number for E-64c is 76684-89-4, and its molecular formula is C15H26N2O5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies E-64c as a research-grade chemical. The specific purity is not detailed in the provided data, and TSS does not represent this product as USP, BP, or EP grade.

What safety precautions should be taken when handling E-64c?

When handling E-64c, it is essential to use personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The substance has a WGK classification of 3 in Germany.