Domperidone
Domperidone (CAS 57808-66-9; C22H24ClN5O2) is a white powder with a molecular weight of 425.91 g/mol. This dopamine antagonist is primarily recognised for its therapeutic applications, acting as a prokinetic agent to aid gastrointestinal motility. It is also utilised in research settings as a biochemical tool for studying dopamine receptor interactions and related cellular processes.
- IUPAC
- 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
Gastrointestinal Motility Agent
Domperidone is used to alleviate symptoms associated with impaired gastrointestinal motility, such as nausea and vomiting. It works by blocking dopamine receptors in the chemoreceptor trigger zone and the gut.
Research Chemical
Utilised in scientific research as a selective antagonist for dopamine D2 receptors. It serves as a valuable tool for investigating the physiological roles of dopamine and its involvement in various biological pathways.
Neuroscience Research
Applied in studies focusing on the central nervous system, particularly in exploring the mechanisms of dopaminergic neurotransmission and its effects on behaviour and cellular signalling.
| Molecular weight | 425.91 |
|---|---|
| Empirical formula | C22H24ClN5O2 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | DMSO: >10 mg/mL0.1 M HCl: soluble0.1 M NaOH: slightly solubleH2O: insoluble |
Hazard statements
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 63-62 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Domperidone used for?
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Domperidone is used as a prokinetic agent to treat symptoms related to gastrointestinal motility disorders, such as nausea and vomiting. It is also used as a research chemical for studying dopamine receptor antagonism and neuroscience.
What is the CAS number and molecular formula for Domperidone?
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The CAS number for Domperidone is 57808-66-9, and its molecular formula is C22H24ClN5O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Domperidone with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Domperidone be handled safely?
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Handle Domperidone with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a respirator with an N100 (US) or P3 (EN143) filter if airborne exposure is possible. Refer to the Safety Data Sheet for detailed handling instructions.
Is Domperidone a controlled substance?
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The provided safety data does not indicate Domperidone is a controlled substance. However, users should consult local regulations.
How is Domperidone shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, providing reliable international shipping and export services for Domperidone.
How can I request a sample or quote for Domperidone?
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Please contact Tech Serve Solutions directly through our website or sales department to request a sample or obtain a quotation for Domperidone.
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