Dodecyldimethylphosphine oxide
Dodecyldimethylphosphine oxide (CAS: 871-95-4), with the linear formula CH3(CH2)11P(O)(CH3)2 and a molecular weight of 246.37 g/mol, is a non-ionic detergent. It is particularly effective for the purification, extraction, and solubilization of membrane-bound proteins, maintaining their native structure. Its stability in water and ease of removal by dialysis make it a valuable reagent in biochemical research, including plasmid DNA isolation.
- IUPAC
- APO-12,Dimethyldodecylphosphine oxide
- Synonyms
- APO-12Dimethyldodecylphosphine oxide
Membrane Protein Solubilization
Dodecyldimethylphosphine oxide serves as a non-ionic detergent for solubilizing membrane proteins. It effectively extracts these proteins while preserving their native structure, facilitating further purification and study.
Protein Purification
This compound is utilised in the purification of proteins, especially those embedded within cell membranes. Its detergent properties aid in their isolation from lipid bilayers.
Biochemical Reagent
As a versatile biochemical reagent, it is employed in various laboratory procedures, including the extraction of cellular components and the isolation of nucleic acids like plasmid DNA.
Dialysis Applications
The detergent's stability in aqueous solutions and its capacity for removal via dialysis make it suitable for applications requiring the subsequent elimination of detergent residues.
| Molecular weight | 246.37 |
|---|---|
| Linear formula | CH3(CH2)11P(O)(CH3)2 |
| Assay | ≥96% (GC) |
| Application | Non-ionic detergent for the purification, extraction and solubilization of membrane-bound proteins in the native structure. It is stable in water and easily removable by dialysis. Useful for plasmid DNA isolation.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Description | non-ionic |
|---|---|
| Mol Wt | micellar avg mol wt 549,965 |
| λ | 1 % in H2O |
| Uv Absorption | λ: 260 nm Amax: 0.2λ: 280 nm Amax: 0.2 |
| Aggregation Number | 2232 |
| Cmc | 0.568 mM(20-25°C) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dodecyldimethylphosphine oxide used for?
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Dodecyldimethylphosphine oxide is a non-ionic detergent used for the purification, extraction, and solubilization of membrane-bound proteins in their native structure. It is also useful for plasmid DNA isolation.
What are the CAS number and formula for Dodecyldimethylphosphine oxide?
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The CAS number for Dodecyldimethylphosphine oxide is 871-95-4, and its linear formula is CH3(CH2)11P(O)(CH3)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Dodecyldimethylphosphine oxide with an assay of ≥96% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Dodecyldimethylphosphine oxide be handled safely?
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Handle Dodecyldimethylphosphine oxide with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid inhalation of dust and ensure adequate ventilation. It is classified with GHS07 symbol and a 'Warning' signal word, with hazard statements H315, H319, and H335.
Is Dodecyldimethylphosphine oxide available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Dodecyldimethylphosphine oxide.
How can I request a quote or sample?
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To request a quote or a sample of Dodecyldimethylphosphine oxide, please contact our sales team through the website or your dedicated account manager.
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