Doxorubicin hydrochloride
Doxorubicin hydrochloride (CAS: 25316-40-9; Formula: C27H29NO11 · HCl; Molar Mass: 579.98) is a potent anthracycline antibiotic with significant antineoplastic properties. Utilised primarily in oncology, it functions by intercalating into DNA and inhibiting topoisomerase II, thereby disrupting DNA replication and cell division. This compound is essential for research in cancer therapy and cell biology.
- IUPAC
- DOX,Hydroxydaunorubicin hydrochloride
- Synonyms
- DOXHydroxydaunorubicin hydrochloride
Cancer Research
Doxorubicin hydrochloride serves as a vital chemotherapeutic agent in the research and development of cancer treatments. Its mechanism of action targeting DNA replication and cell cycle progression makes it a critical tool for studying tumour biology and drug resistance.
Cell Biology Studies
This compound is instrumental in various cell biology research applications, particularly in studies involving apoptosis and cell cycle regulation. Its ability to induce DNA damage and cell death provides insights into cellular responses to genotoxic stress.
Pharmacological Investigations
Doxorubicin hydrochloride is used to investigate drug mechanisms, pharmacokinetics, and pharmacodynamics. Its well-defined cytotoxic effects are valuable for preclinical testing of novel therapeutic strategies and combination therapies.
| Molecular weight | 579.98 |
|---|---|
| Empirical formula | C27H29NO11 · HCl |
| Assay | 98.0-102.0% (HPLC) |
| Solubility | H2O: soluble50 mg/mL, clear, orange to redDMSO: solubleTHF: solubleethanol: solublemethanol: soluble |
| Storage temperature | 2-8°C |
| Suitability | suitable for fluorescence |
| Melting point | 216 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,Xi |
| Risk statements (R) | 45-22-36/38 |
| Safety statements (S) | 53-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 470 nm; λem 585 nm in ethanol |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Doxorubicin hydrochloride used for?
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Doxorubicin hydrochloride is primarily used in cancer research as an antineoplastic agent. It is also employed in cell biology studies to investigate apoptosis and cell cycle regulation, and in pharmacological investigations of drug mechanisms.
What are the CAS number and formula for Doxorubicin hydrochloride?
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The CAS number for Doxorubicin hydrochloride is 25316-40-9, and its empirical formula is C27H29NO11 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Doxorubicin hydrochloride with an assay of 98.0-102.0% (HPLC). We do not represent this product as meeting any specific pharmacopoeia standards such as USP, BP, or EP unless explicitly stated in the product data.
How should Doxorubicin hydrochloride be handled safely?
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Doxorubicin hydrochloride is a dangerous substance. It is harmful if swallowed, causes skin irritation, and causes serious eye irritation. It is also suspected of causing cancer. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 or P3 filters), is essential. Handle only in a well-ventilated area or under a fume hood.
How is Doxorubicin hydrochloride packed, shipped, and exported?
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Doxorubicin hydrochloride is stored at 2-8°C. It is carefully packed and prepared for global export by Tech Serve Solutions, adhering to all relevant shipping regulations for hazardous materials.
How can I request a sample or quote for Doxorubicin hydrochloride?
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To request a sample or a quote for Doxorubicin hydrochloride, please contact our sales team through the website or by phone. We are happy to assist with your research needs.
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