Dimethyl chloromalonate
Dimethyl chloromalonate (CAS: 28868-76-0) with the linear formula ClCH(COOCH3)2 and a molecular weight of 166.56 g/mol, is a key organic building block. This ester features a reactive chlorine atom and two ester functionalities, making it a versatile intermediate in organic synthesis. It is commonly employed in the preparation of more complex molecules within the pharmaceutical and chemical industries.
Organic Synthesis Intermediate
Dimethyl chloromalonate serves as a valuable reagent in carbon-carbon bond formation and the introduction of malonate structures. Its reactivity allows for nucleophilic substitution reactions, facilitating the synthesis of diverse organic compounds.
Pharmaceutical Precursor
It is utilised in the multi-step synthesis of active pharmaceutical ingredients (APIs) and related intermediates. The compound's structure lends itself to building complex molecular frameworks found in various drug candidates.
Research and Development
In academic and industrial research, dimethyl chloromalonate is used for exploring novel synthetic routes and developing new chemical entities. Its well-defined reactivity profile makes it a reliable component in laboratory-scale synthesis.
| Molecular weight | 166.56 |
|---|---|
| Linear formula | ClCH(COOCH3)2 |
| Assay | 94% |
| Boiling point | 105-106 °C/19 mmHg(lit.) |
| Density | 1.305 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.437(lit.) |
| Impurities tested | 4-5% dimethyl dichloromalonate |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 107 °C / 224.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dimethyl chloromalonate used for?
+
Dimethyl chloromalonate (CAS: 28868-76-0) is primarily used as an intermediate in organic synthesis, particularly in the pharmaceutical industry for creating complex molecules and as a building block in research and development.
What are the CAS number and chemical formula for Dimethyl chloromalonate?
+
The CAS number for Dimethyl chloromalonate is 28868-76-0, and its linear formula is ClCH(COOCH3)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Dimethyl chloromalonate with an assay of 94%, containing 4-5% dimethyl dichloromalonate as an impurity. This product is typically supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should Dimethyl chloromalonate be handled safely?
+
Dimethyl chloromalonate is classified as Danger with H314 hazard statement (Causes severe skin burns and eye damage). Handling requires full protective equipment including facesheilds, full-face respirators, gloves, goggles, and appropriate combination respirator cartridges or filters (e.g., type ABEK). Refer to the Safety Data Sheet for comprehensive guidance.
Does Tech Serve Solutions export Dimethyl chloromalonate?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Dimethyl chloromalonate.
How can I request a sample or quote for Dimethyl chloromalonate?
+
To request a sample or quote for Dimethyl chloromalonate, please contact our sales team through the website or by phone, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis