Diisopropylfluorophosphate
Diisopropylfluorophosphate (CAS: 55-91-4), with the molecular formula [(CH3)2CHO]2POF and a molecular weight of 184.15 g/mol, is an organophosphate compound. It is recognised for its potent acetylcholinesterase inhibitory activity. This makes it a valuable tool in biochemical research, particularly for studying enzyme kinetics and the mechanisms of cholinergic neurotransmission. It is also employed in chemical synthesis as a building block.
- IUPAC
- DFP,DIFP,Diisopropyl phosphorofluoridate,Phosphoric acid diisopropyl ester fluoride
- Synonyms
- DFPDIFPDiisopropyl phosphorofluoridatePhosphoric acid diisopropyl ester fluoride
![Diisopropylfluorophosphate ([(CH3)2CHO]2POF) — chemical structure, CAS 55-91-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F55-91-4.png&w=3840&q=75)
Biochemical Research
Diisopropylfluorophosphate is widely used as a potent, irreversible inhibitor of acetylcholinesterase. This property makes it invaluable for studying the physiological roles of acetylcholine and the mechanisms of cholinergic signalling in biological systems.
Enzyme Inhibition Studies
As a highly specific inhibitor, DFP is employed to investigate the active sites and catalytic mechanisms of serine hydrolases, including acetylcholinesterase and other related enzymes, aiding in drug discovery and understanding enzyme function.
Chemical Synthesis
This organophosphate serves as a building block in organic synthesis, particularly for the preparation of phosphorus-containing compounds and other complex molecules in research and development settings.
| Molecular weight | 184.15 |
|---|---|
| Linear formula | [(CH3)2CHO]2POF |
| Assay | ≥97.0% (GC) |
| Boiling point | 62 °C/9 mmHg(lit.) |
| Density | 1.06 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.385(lit.) |
| Solubility | anhydrous isopropanol: soluble0.1-0.5 M (stable for months if stored at -70 °C)H2O: soluble1.5% at 25 °C (very unstable (at pH 7.5, half-life = 1 hr); decomposed by alkali.) |
| Melting point | −82 °C(lit.) |
| Vapour pressure | 0.58 mmHg (20 °C) |
| Storage temperature | 2-8°C |
Hazard statements
- H300Fatal if swallowed
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3382 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PTGS1(5742), PTGS2(5743) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diisopropylfluorophosphate used for?
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Diisopropylfluorophosphate is primarily used as a potent inhibitor of acetylcholinesterase in biochemical research and enzyme studies. It also functions as a building block in chemical synthesis.
What is the CAS number and formula for Diisopropylfluorophosphate?
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The CAS number is 55-91-4 and the molecular formula is [(CH3)2CHO]2POF.
What grade and purity does Tech Serve Solutions supply for Diisopropylfluorophosphate?
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Tech Serve Solutions supplies Diisopropylfluorophosphate with an assay of ≥97.0% (GC). This product is supplied for research and laboratory use. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Diisopropylfluorophosphate be handled safely?
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Diisopropylfluorophosphate is highly toxic and requires careful handling. It is labelled with GHS06 and the signal word 'Danger'. Hazard statements include H300 + H310 + H330, indicating acute toxicity if swallowed, in contact with skin, or if inhaled. Appropriate personal protective equipment, including eyeshields, gloves, and a full-face respirator, must be used. Always consult the Safety Data Sheet (SDS) before use.
How is Diisopropylfluorophosphate packed, shipped, and exported by TSS?
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Diisopropylfluorophosphate is packed according to international regulations for hazardous materials. TSS exports this compound globally, adhering to all relevant shipping and customs requirements for dangerous goods (UN 3382, 6.1 / PGI).
How can I request a quote or sample for Diisopropylfluorophosphate?
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To request a quote or a sample of Diisopropylfluorophosphate, please use the contact form on our website or reach out to our sales team directly. Please specify the quantity required.
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