Difluoromethyl phenyl sulfone
Difluoromethyl phenyl sulfone (CAS: 1535-65-5), with the molecular formula C7H6F2O2S and a molecular weight of 192.18 g/mol, is a valuable reagent in organic synthesis. It is primarily employed for difluoromethylation reactions, enabling the introduction of the difluoromethyl group into various organic molecules. Its applications span the preparation of complex fluorinated compounds, including silanes, amines, and alcohols, making it a key building block for pharmaceutical and agrochemical research.
- IUPAC
- PhSO2CF2H,[(Difluoromethyl)sulfonyl]benzene
Fluoromethylation Reagent
This compound serves as a reagent for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes through the reductive coupling of fluoromethyl sulfones with chlorosilanes.
Fluoroalkylation and Chloroalkylation
It is utilized in the fluoroalkylation or chloroalkylation of various unsaturated systems, including α,β-enones, arynes, and acetylenic ketones, as well as other Michael acceptors.
Difluoromethylation of Halides
Difluoromethyl phenyl sulfone facilitates the difluoromethylation of primary alkyl halides through a nucleophilic substitution-reductive desulfonylation pathway.
Synthesis of Fluorinated Amines
It is employed in the stereoselective synthesis of α-difluoromethyl amines via the (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines.
Preparation of Difluoropropanediols
The reagent aids in the synthesis of anti-difluoropropanediols through the potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.
| Molecular weight | 192.18 |
|---|---|
| Empirical formula | C7H6F2O2S |
| Assay | ≥97% |
| Application | Reagent Used for• Reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes1• Fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors2• Difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation3Reagent used in Preparation of• α-difluoromethyl amines via stereoselective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines4• Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes5• β-difluoromethylated and β-difluoromethylenated alcohols and amines by regioselective nucleophilic difluoromethylation of 1,2-cyclic sulfates and sulfamidates6</su |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Flash point | 128 °C / 262.4 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Difluoromethyl phenyl sulfone used for?
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Difluoromethyl phenyl sulfone is used as a reagent for reductive silylation, fluoroalkylation/chloroalkylation, difluoromethylation of primary alkyl halides, and in the preparation of fluorinated amines and diols.
What is the CAS number and chemical formula for Difluoromethyl phenyl sulfone?
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The CAS number is 1535-65-5 and the chemical formula is C7H6F2O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Difluoromethyl phenyl sulfone with a purity of ≥97%. We do not represent this product as USP, BP, or EP grade.
How should Difluoromethyl phenyl sulfone be handled safely?
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Difluoromethyl phenyl sulfone is a Warning substance (GHS07) and causes skin (H315) and serious eye irritation (H319). Wear protective gloves and eye protection. In case of contact with eyes, rinse cautiously with water for several minutes (P305 + P351 + P338).
How is Difluoromethyl phenyl sulfone packed and shipped?
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This chemical is carefully packed and exported by Tech Serve Solutions, adhering to all necessary transport regulations.
How can I request a sample or quote for Difluoromethyl phenyl sulfone?
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Please contact our sales team via our website or call us to request a sample or a quotation for Difluoromethyl phenyl sulfone.
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