Difluoromethyl 2-pyridyl sulfone

CAS 1219454-89-3C6H5F2NO2SChemical Synthesis

Difluoromethyl 2-pyridyl sulfone (CAS: 1219454-89-3; Formula: C6H5F2NO2S; MW: 193.17) is a specialised reagent for introducing difluoromethyl groups. It is employed in organic synthesis for the olefination of carbonyl compounds to yield gem-difluoro olefins and as an intermediate in constructing 1,1-difluorinated alkyl chains for heterocycle alkylation. This compound is essential for accessing fluorinated organic molecules in research and development.

IUPAC: 2-(Difluoromethylsulfonyl)pyridine,2-[(Difluoromethyl)sulfonyl]pyridine,2-PySO2CF2H,Hu Reagent
Synonyms: 2-(Difluoromethylsulfonyl)pyridine2-[(Difluoromethyl)sulfonyl]pyridine2-PySO2CF2HHu Reagent

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Difluoromethyl 2-pyridyl sulfone (C6H5F2NO2S) — chemical structure, CAS 1219454-89-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisDifluoromethylationFluorination ReagentsSynthetic Reagents

01 /Applications

Olefination of Ketones and Aldehydes

This reagent facilitates the olefination of ketones and aldehydes under basic conditions to produce gem-difluoro olefins. This transformation is valuable for creating fluorinated analogues of alkenes.

Synthesis of Difluorinated Alkyl Chains

It serves as a key intermediate for synthesising 1,1-difluorinated alkyl chains. These chains can subsequently be used for the alkylation of various heterocyclic compounds.

Fluorination Reagent in Organic Synthesis

As a source of the difluoromethyl group, it is a useful tool in synthetic organic chemistry for the incorporation of fluorine into complex molecules.

02 /Properties

Molecular weight	193.17
Empirical formula	C6H5F2NO2S
Assay	97% (HPLC)
Application	Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions.1 Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.2
Melting point	44-49 °C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed
H319Causes serious eye irritation

Precautionary statements

P301IF SWALLOWED
P305IF IN EYES

Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25-36
Safety statements (S)	26-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1219454-89-3

MDL number

MFCD17010193

Beilstein registry

20317604

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Difluoromethyl 2-pyridyl sulfone used for?

Difluoromethyl 2-pyridyl sulfone is used in organic synthesis for the olefination of ketones and aldehydes to form gem-difluoro olefins, and as an intermediate for creating 1,1-difluorinated alkyl chains for heterocycle alkylation.

What are the CAS number and formula for Difluoromethyl 2-pyridyl sulfone?

The CAS number is 1219454-89-3 and the empirical formula is C6H5F2NO2S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Difluoromethyl 2-pyridyl sulfone with an assay of 97% (HPLC). This product is not supplied as USP, BP, or EP grade.

How should Difluoromethyl 2-pyridyl sulfone be handled?

Difluoromethyl 2-pyridyl sulfone is classified as Danger, harmful if swallowed and causes serious eye irritation (H301, H319). Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for full details.