D-Proline
D-Proline (CAS 344-25-2, C5H9NO2, MW 115.13) is a chiral, non-essential amino acid derivative. It is the enantiomer of L-Proline, the naturally occurring form. D-Proline is a valuable building block in organic synthesis, particularly for the creation of chiral molecules and peptides with unique structural properties. Its applications extend to chemical biology and the development of novel chemical entities.
- IUPAC
- (R)-Pyrrolidine-2-carboxylic acid

Chiral Building Block
D-Proline serves as a crucial chiral precursor in asymmetric synthesis. It enables the construction of complex molecules with defined stereochemistry, important in pharmaceutical research and development.
Peptide Synthesis
Incorporated into peptide chains, D-Proline can impart altered conformational stability and resistance to enzymatic degradation. This makes it useful for designing peptidomimetics and therapeutic peptides.
Chemical Biology Research
Used as a tool in chemical biology to probe biological systems and develop novel molecular probes. Its unique stereochemistry can influence interactions with biological targets.
Organic Synthesis
A versatile reagent in various organic transformations, facilitating the synthesis of diverse chemical structures.
| Molecular weight | 115.13 |
|---|---|
| Empirical formula | C5H9NO2 |
| Assay | ≥99% |
| Optical activity | [α]22/D +85.0°, c = 4 in H2O |
| Optical purity | ee: 98% (GLC) |
| Melting point | 223 °C (dec.)(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is D-Proline used for?
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D-Proline is used as a chiral building block in organic synthesis, in peptide chemistry, and in chemical biology research for creating chiral molecules and peptides with specific structural and functional properties.
What are the CAS number and chemical formula for D-Proline?
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The CAS number for D-Proline is 344-25-2, and its empirical formula is C5H9NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies D-Proline with an assay of ≥99% and optical purity of ee: 98%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for D-Proline?
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D-Proline is classified under WGK Germany 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for comprehensive handling information.
How is D-Proline packaged and shipped?
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D-Proline is supplied by Tech Serve Solutions and can be exported globally. Packaging details are available upon request, adhering to international shipping regulations for chemical compounds.
How can I request a sample or quote for D-Proline?
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To request a sample or a quotation for D-Proline, please contact our sales department through the website or direct email, providing your specific requirements.
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