D-Pipecolinic acid
D-Pipecolinic acid (CAS: 1723-00-8; Formula: C6H11NO2; MW: 129.16 g/mol) is a non-proteinogenic amino acid derivative. Also known as (R)-(+)-2-Piperidinecarboxylic acid, it finds application as a chiral building block in chemical synthesis and peptide chemistry. Its specific stereochemistry makes it valuable in the creation of complex molecules and unnatural amino acid derivatives for research purposes.
- IUPAC
- (R)-(+)-2-Piperidinecarboxylic acid,(R)-Piperidine-2-carboxylic acid,D-Homoproline
- Synonyms
- (R)-(+)-2-Piperidinecarboxylic acid(R)-Piperidine-2-carboxylic acidD-Homoproline

Chemical Synthesis
D-Pipecolinic acid serves as a chiral intermediate in the synthesis of complex organic molecules. Its piperidine ring structure is a valuable motif in medicinal chemistry and drug discovery.
Peptide Chemistry
As an unnatural amino acid derivative, D-Pipecolinic acid can be incorporated into peptides to modify their structure and properties. This is useful for developing novel peptide-based therapeutics or research tools.
Chemical Biology
This compound is employed in chemical biology research for probing biological systems or as a component in the synthesis of labelled molecules. Its unique structure can influence biological interactions.
| Molecular weight | 129.16 |
|---|---|
| Empirical formula | C6H11NO2 |
| Assay | 99% |
| Optical activity | [α]25/D +27°, c = 1 in H2O |
| Melting point | 277 °C (dec.)(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is D-Pipecolinic acid used for?
+
D-Pipecolinic acid is primarily used as a chiral building block in chemical synthesis, a component in peptide chemistry for creating unnatural amino acid derivatives, and in chemical biology research.
What are the CAS number and chemical formula for D-Pipecolinic acid?
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The CAS number for D-Pipecolinic acid is 1723-00-8 and its chemical formula is C6H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies D-Pipecolinic acid with an assay of 99%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for D-Pipecolinic acid?
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D-Pipecolinic acid is classified with GHS07 (Warning) and carries hazard statements H315, H319, and H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Recommended personal protective equipment includes a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation.
Is D-Pipecolinic acid a controlled substance?
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The provided data does not indicate that D-Pipecolinic acid is a controlled substance.
How is D-Pipecolinic acid packed and shipped?
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D-Pipecolinic acid is exported by Tech Serve Solutions in compliance with all relevant regulations for chemical transport.
How can I request a quote or sample for D-Pipecolinic acid?
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To request a quote or a sample of D-Pipecolinic acid, please contact our sales team through the TSS website.
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