Coumermycin A1
Coumermycin A1 (CAS: 4434-05-3; C55H59N5O20) is a complex aminocoumarin antibiotic. With a molecular weight of 1110.08 g/mol, it functions as an inhibitor of DNA topoisomerase II, thereby interfering with essential cellular processes like DNA replication and transcription. This compound is valuable in biochemical research for studying these mechanisms and has been explored for its therapeutic potential, including in models of bacterial infections.
Study of DNA Replication and Transcription
Coumermycin A1 is utilised as a biochemical tool to investigate DNA topoisomerase II activity. Its inhibitory effects provide insights into the mechanisms of DNA replication, transcription, and recombination within cellular systems.
Bacterial Infection Research
This antibiotic has been employed in preclinical research, such as in a rat model for treating Staphylococcus aureus endocarditis. It aids in understanding antibiotic efficacy against specific bacterial strains.
Gene Expression Analysis
The compound has been used to study the impact of DNA topology on gene expression, for instance, by examining its effect on the expression of fusions in bacterial systems like Salmonella typhimurium.
| Molecular weight | 1110.08 |
|---|---|
| Empirical formula | C55H59N5O20 |
| Application | Coumermycin A1 is an aminocoumarin antibiotic used to study processes such as DNA replication, transcription, and recombination that involve DNA topoisomerase II activity. It has been used to treat Staphylococcus aureus endocarditis in the rat model1 and to study the effect of coumermycin A1 on the expression of 67 fusions in Salmonella typhimurium. 2. |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Coumermycin A1 used for?
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Coumermycin A1 is primarily used in research to study DNA replication, transcription, and recombination by inhibiting DNA topoisomerase II. It has also been investigated in models for treating bacterial infections and analysing gene expression.
What are the CAS number and formula for Coumermycin A1?
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The CAS number for Coumermycin A1 is 4434-05-3, and its empirical formula is C55H59N5O20.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Coumermycin A1 typically for research purposes. The specific grade and purity are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Coumermycin A1 be handled safely?
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Coumermycin A1 is classified as harmful if swallowed and requires careful handling. Recommended personal protective equipment includes a dust mask (N95), eyeshields, and gloves. Always consult the Safety Data Sheet (SDS) before use.
How is Coumermycin A1 packed and shipped?
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Coumermycin A1 is carefully packed according to international shipping regulations for chemical compounds. Tech Serve Solutions is an experienced global exporter, ensuring compliance with all necessary documentation and standards for secure transit.
How can I request a quote or sample for Coumermycin A1?
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To request a quote or a sample of Coumermycin A1, please contact our sales team via the website or email. Provide your contact details and the quantity required for an efficient response.
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