Chlorodiisopropylsilane
Chlorodiisopropylsilane (CAS 2227-29-4), with the linear formula [(CH3)2CH]2SiHCl and a molecular weight of 150.72 g/mol, is a versatile organosilicon compound. It serves as a valuable reagent in chemical synthesis, particularly for the introduction of the diisopropylsilyl protecting group onto alcohols and other nucleophiles. Its reactivity profile makes it a useful intermediate in the preparation of more complex silicon-containing molecules.
- IUPAC
- Diisopropylchlorosilane
- Synonyms
- Diisopropylchlorosilane
![Chlorodiisopropylsilane ([(CH3)2CH]2SiHCl) — chemical structure, CAS 2227-29-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F2227-29-4.png&w=3840&q=75)
Protecting Group Chemistry
Chlorodiisopropylsilane is extensively used to install the diisopropylsilyl (DIPS) ether protecting group on alcohols. This robust protecting group is stable under a range of reaction conditions and can be selectively removed when needed.
Organic Synthesis Intermediate
As a silicon-based reagent, it acts as a building block or intermediate in the synthesis of various organic compounds, facilitating the formation of new carbon-silicon bonds or serving as a precursor for other organosilane derivatives.
Derivatization Agent
The compound can be employed as a derivatizing agent in analytical chemistry, particularly for chromatography, enabling the detection and quantification of specific analytes by altering their volatility or detectability.
| Molecular weight | 150.72 |
|---|---|
| Linear formula | [(CH3)2CH]2SiHCl |
| Assay | 99% |
| Boiling point | 58-60 °C/50 mmHg(lit.) |
| Density | 0.883 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.429(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 38 °C / 100.4 °F |
| Transport (UN / ADR) | UN 2986 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorodiisopropylsilane used for?
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Chlorodiisopropylsilane is primarily used as a protecting group reagent, particularly for installing the diisopropylsilyl (DIPS) ether group on alcohols. It also serves as a useful intermediate in organic synthesis and for derivatization.
What is the CAS number and formula for Chlorodiisopropylsilane?
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The CAS number is 2227-29-4 and the linear formula is [(CH3)2CH]2SiHCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chlorodiisopropylsilane with an assay of 99%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Chlorodiisopropylsilane be handled safely?
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Chlorodiisopropylsilane is a flammable liquid and causes severe skin burns and eye damage (Danger: H226-H314). Handle with extreme care, wearing appropriate personal protective equipment including a full-face respirator, chemical-resistant gloves, and eye protection. Ensure adequate ventilation and avoid ignition sources.
How is Chlorodiisopropylsilane packed, shipped, and exported?
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Chlorodiisopropylsilane is shipped as a UN 2986, Hazard Class 3 (8), Packing Group II substance. TSS is a specialist global supplier and exporter, adhering to all relevant shipping and export regulations.
How can I request a sample or quote for Chlorodiisopropylsilane?
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To request a sample or quote for Chlorodiisopropylsilane, please use the contact form on our website or contact our sales department directly.
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