Z-Leu-Leu-Glu β-naphthylamide
Z-Leu-Leu-Glu β-naphthylamide (CAS: 75873-85-7) is a chemical compound with the formula C35H44N4O7 and a molecular weight of 632.75 g/mol. This white powder serves as a valuable tool in biochemical research, particularly for studying enzyme activity and cellular processes. It is widely employed as a substrate for enzymes involved in protein degradation and cell signaling.
- IUPAC
- Cbz-LLE β-naphthylamine
Enzyme Substrate
Z-Leu-Leu-Glu β-naphthylamide is used as a chromogenic substrate for enzymes that cleave peptide bonds, such as glutamylpeptidyl-peptide hydrolase. The release of β-naphthylamine allows for spectrophotometric quantification of enzyme activity.
Protease Research
This compound is employed in studies investigating the function and inhibition of proteases, including calpains and proteasome components. It aids in understanding protein turnover and intracellular degradation pathways.
Cell Biology Studies
As a bioactive small molecule, it is utilized in cell biology to probe signaling pathways and cellular stress responses, particularly those involving nitric oxide and proteolysis.
| Molecular weight | 632.75 |
|---|---|
| Empirical formula | C35H44N4O7 |
| Assay | ≥98% |
| Form | powder |
| Colour | white |
| Storage temperature | −20°C |
Hazard statements
- H351Suspected of causing cancer
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 40 |
| Safety statements (S) | 22-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Z-Leu-Leu-Glu β-naphthylamide used for?
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Z-Leu-Leu-Glu β-naphthylamide is primarily used as an enzyme substrate in biochemical research, for studying protease activity (including calpain and proteasome), and in cell biology to investigate signaling pathways and protein degradation.
What is the CAS number and formula for Z-Leu-Leu-Glu β-naphthylamide?
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The CAS number is 75873-85-7, and the empirical formula is C35H44N4O7.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Z-Leu-Leu-Glu β-naphthylamide with a purity of ≥98%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Z-Leu-Leu-Glu β-naphthylamide be handled safely?
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Z-Leu-Leu-Glu β-naphthylamide is classified with GHS08 symbol and a 'Warning' signal word, carrying hazard statement H351 (Suspected of causing cancer). Appropriate personal protective equipment includes eyeshields, gloves, and a suitable respirator (e.g., N100 US type). Handle with care, avoiding dust formation and ensuring adequate ventilation.
How is Z-Leu-Leu-Glu β-naphthylamide typically shipped?
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This chemical is typically stored at -20°C. TSS professionally packs and exports chemicals globally, adhering to all relevant shipping regulations.
How can I request a sample or quote for Z-Leu-Leu-Glu β-naphthylamide?
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To request a sample or a quotation, please contact our sales department via the website or email, providing your contact details and the product's CAS number (75873-85-7).
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