Chlorodifluoroacetic anhydride
Chlorodifluoroacetic anhydride (CAS 2834-23-3), with the linear formula (ClCF2CO)2O and a molecular weight of 242.94 g/mol, is a reactive carboxylic acid anhydride. It is primarily utilised as a specialised building block in organic synthesis and as a derivatisation reagent. Its applications include the dual element acetylation tagging of amines and the determination of steroid hormones like estrone and 17β-estradiol.
Derivatisation Reagent for Amine Analysis
Chlorodifluoroacetic anhydride serves as an acetylation tagging reagent for amines. This application is particularly useful in conjunction with microwave-sustained helium emission detection for analytical purposes.
Steroid Hormone Determination
This compound is employed as a derivatisation reagent in gas chromatography-mass spectrometry (GC-MS) methods. It facilitates the accurate determination of hormones such as estrone and 17β-estradiol in biological samples like hair.
Fluorinated Organic Synthesis
As a fluorinated building block, chlorodifluoroacetic anhydride is valuable in the synthesis of complex organic molecules containing fluorine. Its reactivity allows for the introduction of the chlorodifluoroacetyl group into various substrates.
| Molecular weight | 242.94 |
|---|---|
| Linear formula | (ClCF2CO)2O |
| Assay | 98% |
| Boiling point | 96-97 °C(lit.) |
| Density | 1.395 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.347(lit.) |
| Application | Chlorodifluoroacetic anhydride has been used:• for dual element acetylation tagging derivatization of amines by using microwave sustained helium emission detector1• as derivatization reagent in determination of estrone and 17β-estradiol in hair by GC-MS2 |
Hazard statements
- H301Toxic if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 21/22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorodifluoroacetic anhydride used for?
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Chlorodifluoroacetic anhydride is used as a derivatisation reagent for the analysis of amines and steroids, and as a building block in fluorinated organic synthesis.
What is the CAS number and formula for Chlorodifluoroacetic anhydride?
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The CAS number is 2834-23-3, and the linear formula is (ClCF2CO)2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chlorodifluoroacetic anhydride with a minimum purity of 98%. This product is intended for research and chemical synthesis and is not supplied as USP, BP, or EP grade.
How should Chlorodifluoroacetic anhydride be handled safely?
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Chlorodifluoroacetic anhydride is a dangerous substance that causes severe skin burns and eye damage, is harmful if swallowed, and harmful in contact with skin. Appropriate personal protective equipment, including chemical-resistant gloves, eye protection (goggles and face shield), and respiratory protection, must be used. Handle only in a well-ventilated area or fume hood.
Is Chlorodifluoroacetic anhydride available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Chlorodifluoroacetic anhydride.
How can I request a quote or sample?
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To request a quote or sample of Chlorodifluoroacetic anhydride, please contact our sales department through the website or by phone.
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