Chlorodimethyl(pentafluorophenyl)silane
Chlorodimethyl(pentafluorophenyl)silane (CAS: 20082-71-7), with the molecular formula C6F5Si(CH3)2Cl and a molecular weight of 260.66 g/mol, is a specialised organosilicon compound. It features a highly fluorinated aromatic ring and a reactive chlorosilane moiety. This structure makes it a valuable reagent in organic synthesis, particularly for introducing the (pentafluorophenyl)dimethylsilyl group, which can serve as a protecting group or a derivatizing agent in various chemical transformations.
- IUPAC
- (Pentafluorophenyl)dimethylchlorosilane,Flophemesyl chloride
- Synonyms
- (Pentafluorophenyl)dimethylchlorosilane, Flophemesyl chloride

Protecting Group Chemistry
Used to introduce the (pentafluorophenyl)dimethylsilyl group, which can protect sensitive functional groups such as alcohols and amines during multi-step syntheses. The fluorinated nature of the protecting group can offer unique solubility and reactivity characteristics.
Derivatization Reagent
Employed as a derivatizing agent in analytical chemistry, particularly for gas chromatography. The introduction of the heavy, fluorinated pentafluorophenyl group can enhance detection sensitivity and alter chromatographic behaviour.
Organic Synthesis Intermediate
Acts as a building block in the synthesis of more complex organosilicon compounds or fluorinated organic molecules. Its reactive Si-Cl bond allows for nucleophilic substitution reactions.
| Molecular weight | 260.66 |
|---|---|
| Linear formula | C6F5Si(CH3)2Cl |
| Assay | 96% |
| Boiling point | 88-90 °C/10 mmHg(lit.) |
| Density | 1.384 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.448(lit.) |
| Flash point | 75 °C / 167 °F |
|---|---|
| Transport (UN / ADR) | UN 2987 8/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorodimethyl(pentafluorophenyl)silane used for?
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Chlorodimethyl(pentafluorophenyl)silane is primarily used as a protecting and derivatizing reagent in chemical synthesis. It is employed to introduce the (pentafluorophenyl)dimethylsilyl group, which can protect functional groups or aid in analytical derivatization, particularly in gas chromatography.
What are the CAS number and formula for Chlorodimethyl(pentafluorophenyl)silane?
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The CAS number is 20082-71-7 and the linear formula is C6F5Si(CH3)2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chlorodimethyl(pentafluorophenyl)silane with a minimum assay of 96%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations when handling this chemical?
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This compound is corrosive and may cause severe burns to skin and eyes, and respiratory irritation. Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for full hazard information.
How is Chlorodimethyl(pentafluorophenyl)silane packed and shipped?
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Chlorodimethyl(pentafluorophenyl)silane is packed and shipped according to international regulations for hazardous materials. For specific shipping and export details, please contact our sales team.
How can I request a sample or quote?
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To request a sample or a quotation for Chlorodimethyl(pentafluorophenyl)silane, please visit the product page and use the 'Request a Quote' or 'Sample Request' form, or contact our customer service team directly.
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