Chlorodimethylsilane
Chlorodimethylsilane (CAS 1066-35-9), with the linear formula (CH3)2SiHCl and a molecular weight of 94.62, is a versatile organosilicon compound. It is primarily utilized in chemical synthesis as a reagent for preparing vinyldimethylsilanols. These intermediates are crucial for palladium-catalyzed cross-coupling reactions with aryl iodides, facilitating the formation of complex organic molecules. Its properties make it a valuable building block in organic chemistry research and development.
- IUPAC
- DMCS,Dimethylchlorosilane
- Synonyms
- DMCS,Dimethylchlorosilane
Synthesis of Vinyldimethylsilanols
Chlorodimethylsilane serves as a key precursor for synthesizing vinyldimethylsilanols. This process is essential for creating intermediates used in subsequent cross-coupling reactions.
Palladium-Catalyzed Cross-Coupling
The vinyldimethylsilanols derived from Chlorodimethylsilane are employed in palladium-catalyzed cross-coupling reactions, particularly with aryl iodides, enabling efficient carbon-carbon bond formation.
Organic Synthesis Reagent
As a silicon-based compound, it acts as a valuable reagent in various organic synthesis pathways, contributing to the construction of diverse molecular architectures.
| Molecular weight | 94.62 |
|---|---|
| Linear formula | (CH3)2SiHCl |
| Assay | ≥95.0% (GC) |
| Boiling point | 34.7 °C(lit.) |
| Density | 0.852 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.382n20/D 1.383(lit.) |
| Vapour pressure | 8.56 psi (20 °C) |
| Melting point | −111 °C(lit.) |
| Vapour density | 4 (vs air) |
| Application | Used to prepare vinyldimethylsilanols for palladium-catalyzed cross-coupling with aryl iodides.1 |
Hazard statements
- H225Highly flammable liquid and vapour
- H260In contact with water releases flammable gases
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -23 °C / -9.4 °F |
| Transport (UN / ADR) | UN 2988 4.3/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorodimethylsilane used for?
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Chlorodimethylsilane (CAS 1066-35-9) is used to prepare vinyldimethylsilanols for palladium-catalyzed cross-coupling with aryl iodides.
What is the CAS number and formula for Chlorodimethylsilane?
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The CAS number is 1066-35-9 and the linear formula is (CH3)2SiHCl.
What grade and purity does Tech Serve Solutions supply for Chlorodimethylsilane?
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Tech Serve Solutions supplies Chlorodimethylsilane with a purity of ≥95.0% (GC). We do not represent this product as USP, BP, or EP grade unless explicitly stated in the specifications.
How should Chlorodimethylsilane be handled safely?
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Chlorodimethylsilane is a highly flammable liquid and vapour (H225) and reacts violently with water, releasing flammable gas (H260). It causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, and should be done in a well-ventilated area away from ignition sources and water.
How is Chlorodimethylsilane packed and shipped?
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Chlorodimethylsilane is packed in compliance with transportation regulations for hazardous materials. TSS exports this chemical globally, adhering to all international shipping standards for dangerous goods.
How can I request a quote or sample for Chlorodimethylsilane?
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To request a quote or sample of Chlorodimethylsilane, please contact our sales team through the TSS website or by phone.
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