Chlorodipyrrolidinocarbenium hexafluorophosphate
Chlorodipyrrolidinocarbenium hexafluorophosphate (CAS: 135540-11-3), with the molecular formula C9H16N2Cl · PF6 and a molecular weight of 332.65, is a valuable reagent in organic synthesis. It functions effectively as a reactant in various chemical transformations, including peptide coupling and the enantioselective desymmetrization of meso-asiridines. Additionally, it serves as a key reagent for heterocyclization reactions and the synthesis of palladium and nickel catalysts.
- IUPAC
- N,N,N′,N′-Bis(tetramethylene)chloroformamidinium hexafluorophosphate,Chloro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate,PyClU
- Synonyms
- N,N,N′,N′-Bis(tetramethylene)chloroformamidinium hexafluorophosphateChloro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphatePyClU
Peptide Coupling
This compound is utilised as a reagent in peptide coupling reactions, facilitating the formation of amide bonds crucial for peptide synthesis. Its efficacy in this area contributes to the efficient construction of peptide chains.
Enantioselective Desymmetrization
It serves as a reactant for the enantioselective desymmetrization of meso-asiridines. This application is important in asymmetric synthesis for generating chiral intermediates.
Catalyst Synthesis
Chlorodipyrrolidinocarbenium hexafluorophosphate is employed in oxidative insertion reactions for the synthesis of palladium and nickel catalysts, supporting various catalytic cycles in organic chemistry.
Heterocyclization Reactions
The reagent is used in the heterocyclization of chloroformamidinium salts, enabling the formation of heterocyclic ring systems which are common motifs in pharmaceuticals and materials.
| Molecular weight | 332.65 |
|---|---|
| Linear formula | C9H16N2Cl · PF6 |
| Assay | ≥98.0% (CHN) |
| Storage temperature | 2-8°C |
| Application | Reactant for: Enantioselective desymmetrization of meso-asiridines1 Peptide coupling2Reagent for: Heterocyclization of chloroformamidinium salts3 Oxidative insertion for palladium and nickel catalyst synthesis4 |
| Melting point | 153-156 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorodipyrrolidinocarbenium hexafluorophosphate used for?
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Chlorodipyrrolidinocarbenium hexafluorophosphate is used as a reactant for enantioselective desymmetrization of meso-asiridines and peptide coupling, and as a reagent for heterocyclization of chloroformamidinium salts and oxidative insertion for palladium and nickel catalyst synthesis.
What are the CAS number and formula for Chlorodipyrrolidinocarbenium hexafluorophosphate?
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The CAS number is 135540-11-3, and the chemical formula is C9H16N2Cl · PF6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥98.0% (CHN). This is a technical or research grade, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should Chlorodipyrrolidinocarbenium hexafluorophosphate be handled safely?
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This compound is a warning irritant (H315, H319, H335). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation.
Is this product available for international export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a sample or quote?
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Please contact our sales team directly through the website or by phone to request a sample or a quotation for Chlorodipyrrolidinocarbenium hexafluorophosphate.
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