Chloroacetyl isocyanate
Chloroacetyl isocyanate (CAS 4461-30-7), with the linear formula ClCH2CONCO and a molecular weight of 119.51 g/mol, is a reactive organic compound. It is primarily utilised as a building block in chemical synthesis. This isocyanate derivative plays a role in the creation of various complex organic molecules, including certain pharmaceutical intermediates and research chemicals, demanding careful handling due to its reactivity.
Synthesis of Fumagillin Analogues
Chloroacetyl isocyanate serves as a key intermediate in the synthetic pathways leading to analogues of fumagillin, a naturally occurring compound with known biological activities. Its incorporation allows for the construction of specific structural motifs required for these analogues.
Preparation of Heterocyclic Compounds
This compound is employed in the synthesis of specific cyclic acetamides, such as 2-chloro-N-(4-oxocyclopent-2-enyl)-acetamide. This application highlights its utility in forming nitrogen-containing heterocyclic structures.
Reagent in Organic Synthesis
As a versatile building block, chloroacetyl isocyanate is utilised in general organic synthesis for introducing the chloroacetyl isocyanate moiety into various molecular frameworks. This enables the creation of novel chemical entities for research and development.
| Molecular weight | 119.51 |
|---|---|
| Linear formula | ClCH2CONCO |
| Assay | ≥95% |
| Boiling point | 50-55 °C/20 mmHg(lit.) |
| Density | 1.403 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.463(lit.) |
| Storage temperature | −20°C |
| Application | Chloroacetyl isocyanate has been used in the synthesis of:• fumagillin analogs1• 2-chloro-N-(4-oxocyclopent-2-enyl)-acetamide2 |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H334May cause allergy or asthma symptoms if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 62 °C / 143.6 °F |
| Transport (UN / ADR) | UN 2922 8/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 14-25-34-42 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chloroacetyl isocyanate used for?
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Chloroacetyl isocyanate is primarily used as a building block in chemical synthesis for creating complex organic molecules, including fumagillin analogues and specific cyclic acetamides.
What is the CAS number and formula for Chloroacetyl isocyanate?
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The CAS number for Chloroacetyl isocyanate is 4461-30-7 and its linear formula is ClCH2CONCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chloroacetyl isocyanate with a minimum assay of ≥95%. We do not represent this product as USP, BP, EP, or any pharmacopoeial grade.
How should Chloroacetyl isocyanate be handled safely?
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Chloroacetyl isocyanate is a dangerous substance that reacts violently with water. It is corrosive and toxic. Handle with extreme care, using appropriate personal protective equipment including a faceshield, chemical-resistant gloves, and a suitable respirator. Ensure adequate ventilation and avoid contact with skin, eyes, and clothing.
How is Chloroacetyl isocyanate packed, shipped, and exported?
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We expertly pack, ship, and export Chloroacetyl isocyanate globally, adhering to all relevant safety and transportation regulations for hazardous materials.
How can I request a sample or quote for Chloroacetyl isocyanate?
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To request a sample or a quotation for Chloroacetyl isocyanate, please contact our sales team through the website or via direct inquiry, specifying your requirements.
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