Chloroacetic anhydride
Chloroacetic anhydride (CAS 541-88-8), with the linear formula (ClCH₂CO)₂O and a molecular weight of 170.98 g/mol, is a reactive carboxylic acid anhydride. It is primarily utilised as a building block in organic synthesis, particularly in the introduction of the chloroacetyl group. This compound serves as a key intermediate in the production of various chemical entities within the fine chemical and pharmaceutical sectors.
- IUPAC
- Monochloroacetic acid anhydride
- Synonyms
- Monochloroacetic acid anhydride
Organic Synthesis Reagent
Chloroacetic anhydride is employed as an acylating agent to introduce the chloroacetyl moiety into organic molecules. This is a fundamental step in the synthesis of more complex compounds.
Pharmaceutical Intermediate
Its reactivity makes it valuable in the multi-step synthesis of active pharmaceutical ingredients (APIs) and related chemical entities.
Chemical Research and Development
Used in laboratories for exploring new synthetic pathways and developing novel compounds.
| Molecular weight | 170.98 |
|---|---|
| Linear formula | (ClCH2CO)2O |
| Assay | 95% |
| Boiling point | 120-123 °C/20 mmHg(lit.) |
| Solubility | chloroform: soluble100 mg/mL, clear, colorless to faintly yellow |
| Vapour pressure | <0.75 mmHg (20 °C) |
| Melting point | 48-60 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 143 °C / 289.4 °F |
| Transport (UN / ADR) | UN 2928 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-34-43 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chloroacetic anhydride used for?
+
Chloroacetic anhydride is used as a building block in organic synthesis for introducing the chloroacetyl group and as an intermediate in the preparation of pharmaceuticals and other fine chemicals.
What is the CAS number and formula for Chloroacetic anhydride?
+
The CAS number is 541-88-8 and the linear formula is (ClCH₂CO)₂O.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Chloroacetic anhydride with an assay of 95%. We do not represent this product as USP, BP, or EP grade.
How should Chloroacetic anhydride be handled safely?
+
Chloroacetic anhydride is a Danger material (GHS05, GHS06) that causes severe skin burns and eye damage (H314), is toxic if swallowed (H301), and may cause an allergic skin reaction (H317). Appropriate personal protective equipment, including eyeshields, face shields, and resistant gloves, is essential. Handle in a well-ventilated area.
How is Chloroacetic anhydride packed and shipped?
+
Tech Serve Solutions exports Chloroacetic anhydride in compliance with all relevant regulations for hazardous materials. Specific packaging details can be provided upon request.
How can I request a quote or sample for Chloroacetic anhydride?
+
Please contact our sales team via the website or direct email to request a quote or sample of Chloroacetic anhydride.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis