Bromonitromethane

CAS 563-70-2BrCH2NO2Chemical Synthesis

Bromonitromethane (CAS 563-70-2), with the linear formula BrCH₂NO₂, is an organic compound with a molecular weight of 139.94 g/mol. This nitro compound serves as a valuable building block in chemical synthesis, particularly for the creation of Umpolung amide functionalities and the preparation of bromonitroalkene derivatives. Its applications span advanced organic synthesis and the development of novel chemical entities.

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Bromonitromethane (BrCH2NO2) — chemical structure, CAS 563-70-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksChemical SynthesisNitro CompoundsNitrogen CompoundsOrganic Building Blocks

01 /Applications

Protected α-bromo nitroalkane Donors

Bromonitromethane is utilised in the production of various protected α-bromo nitroalkane donors, including Fmoc derivatives. These compounds are essential for employing Umpolung strategies in amide synthesis, allowing for novel bond formations.

Preparation of (Z)-1-bromo-1-nitroalkenes

This reagent is employed in the preparation of (Z)-1-bromo-1-nitroalkenes. The synthesis is facilitated by a sodium iodide-catalysed Henry reaction, providing a specific route to these unsaturated nitro compounds.

Cyclopropanation Reactions

In diastereo- and enantioselective cyclopropanation of β,γ-unsaturated α-ketoesters, bromonitromethane plays a role. It is used within a domino Michael-addition/intramolecular-alkylation strategy for complex molecule construction.

02 /Properties

Molecular weight	139.94
Linear formula	BrCH2NO2
Assay	90%
Boiling point	146-148 °C/750 mmHg(lit.)
Density	2.007 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.496(lit.)
Application	Bromonitromethane has been used:• in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis1• in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction2• in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy3

03 /Safety & handling

GHS hazard pictogram: Oxidising (GHS03) — Oxidising

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Danger

Hazard statements

H272May intensify fire; oxidiser
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P220Keep away from clothing and combustible materials
P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Flash point	113 °C / 235.4 °F
Transport (UN / ADR)	UN 3139 5.1 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	O,Xi
Risk statements (R)	8-36/37/38
Safety statements (S)	17-26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

563-70-2

MDL number

MFCD00007401

PubChem substance

24855488

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Bromonitromethane used for?

Bromonitromethane is used as a building block in chemical synthesis, including the production of protected α-bromo nitroalkane donors for Umpolung amide synthesis, the preparation of (Z)-1-bromo-1-nitroalkenes, and in diastereo- and enantioselective cyclopropanation reactions.

What are the CAS number and formula for Bromonitromethane?

The CAS number for Bromonitromethane is 563-70-2, and its linear formula is BrCH₂NO₂.

What grade and purity does Tech Serve Solutions supply for Bromonitromethane?

Tech Serve Solutions supplies Bromonitromethane with an assay of 90%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should Bromonitromethane be handled safely?

Bromonitromethane is classified under GHS03 and GHS07 with the signal word 'Danger'. It carries hazard statements H272 (May intensify fire; oxidiser), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (e.g., N100 or P3 filters), is essential. Handle in a well-ventilated area and keep away from ignition sources.

Is Bromonitromethane a controlled substance?

The provided data does not indicate that Bromonitromethane is a controlled substance.

How is Bromonitromethane packaged and exported?

Bromonitromethane is shipped under UN 3139, hazard class 5.1 (oxidiser), Packing Group II. TSS ensures compliant packaging and export procedures for this material.

How can I request a sample or quote for Bromonitromethane?

To request a sample or a quotation for Bromonitromethane, please contact the Tech Serve Solutions sales team via our website or direct contact details.