Bromomethyl methyl ether
Bromomethyl methyl ether (CAS: 13057-17-5) is an organic ether with the linear formula BrCH2OCH3 and a molecular weight of 124.96 g/mol. This compound is primarily utilised as a building block in organic synthesis. It has found application in the enantiocontrolled synthesis of complex molecules, including intermediates for pharmaceuticals like the immunosuppressant FK-506.
Pharmaceutical Intermediate Synthesis
Bromomethyl methyl ether has been employed in the synthesis of key intermediates for pharmaceutical agents. For example, it was used in the enantiocontrolled synthesis of a fragment of the macrocyclic immunosuppressant FK-506.
Organic Synthesis Building Block
As a versatile building block, this ether is valuable in creating carbon-carbon bonds and introducing specific functional groups. Its reactivity makes it useful in multi-step syntheses of complex organic molecules.
Azetidinone Synthesis
The compound has been utilised in the synthesis of substituted azetidinones, such as 1-methoxymethyl-4-tritylthio-2-azetidinone, which can serve as intermediates in further chemical transformations.
| Molecular weight | 124.96 |
|---|---|
| Linear formula | BrCH2OCH3 |
| Assay | 90% |
| Grade | technical grade |
| Boiling point | 87 °C(lit.) |
| Density | 1.531 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.456(lit.) |
| Storage temperature | 2-8°C |
| Application | Bromomethyl methyl ether was used in enantiocontrolled synthesis of intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-5061. It was used in the synthesis of 1-methoxymethyl-4-tritylthio-2-azetidinone2. |
Hazard statements
- H226Flammable liquid and vapour
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 27 °C / 80.6 °F |
| Transport (UN / ADR) | UN 1992 3/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37/38-40 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bromomethyl methyl ether used for?
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Bromomethyl methyl ether is used as a building block in organic synthesis, particularly in the pharmaceutical industry for creating complex intermediates, such as those found in the synthesis of FK-506 and azetidinone derivatives.
What are the CAS number and chemical formula for Bromomethyl methyl ether?
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The CAS number for Bromomethyl methyl ether is 13057-17-5, and its linear formula is BrCH2OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bromomethyl methyl ether in technical grade with an assay of 90%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety concerns when handling Bromomethyl methyl ether?
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Bromomethyl methyl ether is a flammable liquid (H226) and is harmful if swallowed, inhaled, or in contact with skin (H302, H332, H312). It can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). There is also a suspected risk of cancer (H351). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, must be used in a well-ventilated area.
How is Bromomethyl methyl ether packed, shipped, and exported?
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Bromomethyl methyl ether is packed and shipped in compliance with international regulations for hazardous materials, including UN 1992, Class 3, Packing Group 3. As a global supplier, Tech Serve Solutions exports this chemical worldwide.
How can I request a sample or quote for Bromomethyl methyl ether?
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To request a sample or quote for Bromomethyl methyl ether, please contact our sales department via the website or direct email, providing your contact details and required quantity.
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