Boc-Cys(Trt)-OH

CAS 21947-98-8(C6H5)3CSCH2CH[NHCO2C(CH3)3]CO2HChemical Synthesis

N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine (CAS 21947-98-8) is a protected amino acid derivative with a molecular weight of 463.59 g/mol. It features a tert-butoxycarbonyl (Boc) group for N-terminal protection and a trityl (Trt) group for thiol protection of the cysteine side chain. This compound is primarily utilised in peptide synthesis and chemical biology research for the controlled incorporation of cysteine residues into peptide chains.

IUPAC: N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine,Nα-Boc-S-trityl-L-cysteine
Synonyms: N-(tert-Butoxycarbonyl)-S-trityl-L-cysteineNα-Boc-S-trityl-L-cysteine

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Boc-Cys(Trt)-OH ((C6H5)3CSCH2CH[NHCO2C(CH3)3]CO2H) — chemical structure, CAS 21947-98-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisCysteine/CystinePeptide Chemistry

01 /Applications

Peptide Synthesis

Utilised as a building block in solid-phase or solution-phase peptide synthesis. The orthogonal protecting groups (Boc and Trt) allow for selective deprotection strategies, crucial for constructing complex peptide sequences.

Chemical Biology

Serves as a key intermediate for preparing modified peptides or peptidomimetics. Its protected form facilitates specific chemical modifications at the cysteine residue during biological studies.

Organic Synthesis

Employed in the synthesis of various organic molecules where a protected cysteine moiety is required. The trityl group offers robust protection for the thiol under various reaction conditions.

02 /Properties

Molecular weight	463.59
Linear formula	(C6H5)3CSCH2CH[NHCO2C(CH3)3]CO2H
Assay	97%
Optical activity	[α]20/D +27.5°, c = 1 in ethanol
Melting point	143-146 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

21947-98-8

Beilstein registry

2028965

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Cys(Trt)-OH used for?

Boc-Cys(Trt)-OH is primarily used as a protected amino acid derivative in peptide synthesis and chemical biology research for the controlled incorporation of cysteine residues into peptide chains.

What is the CAS number and formula for Boc-Cys(Trt)-OH?

The CAS number is 21947-98-8. The linear formula is (C 6 H 5 ) 3 CSCH 2 CH[NHCO 2 C(CH 3 ) 3 ]CO 2 H.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Cys(Trt)-OH with an assay of 97%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or other pharmacopoeia grades.

What are the safety considerations when handling Boc-Cys(Trt)-OH?

Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Consult the Safety Data Sheet for full details. The WGK Germany classification is 3.

How is Boc-Cys(Trt)-OH packed, shipped, and exported?

As a specialist global supplier, Tech Serve Solutions ensures appropriate packaging for safe transport and export of chemical products in compliance with international regulations.