(±)-Baclofen
(±)-Baclofen (CAS: 1134-47-0) is a chloro-substituted derivative of gamma-aminobutyric acid (GABA). This white to very faintly yellow solid, with a molecular weight of 213.66 g/mol, functions as a GABAB receptor agonist. It is primarily utilised in neuroscience research for its muscle relaxant and antispasmodic properties, offering a valuable tool for studying neuronal pathways and related physiological responses.
- IUPAC
- (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid,Lioresal
- Synonyms
- (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acidLioresal
Neuroscience Research
As a selective GABAB receptor agonist, (±)-Baclofen is extensively used to investigate the role of GABAergic signaling in the central nervous system. It aids in understanding neurotransmission, muscle spasticity, and pain pathways.
Pharmacological Tool
Its specific action at GABAB receptors makes it a key compound for in vitro and in vivo studies exploring neurological disorders and potential therapeutic targets. Researchers utilise it to probe receptor function and downstream signalling cascades.
Chemical Synthesis Intermediate
(±)-Baclofen can serve as a building block or reference compound in the synthesis of novel molecules with potential biological activity. Its established structure provides a basis for medicinal chemistry explorations.
| Molecular weight | 213.66 |
|---|---|
| Empirical formula | C10H12ClNO2 |
| Assay | ≥98% (TLC) |
| Form | solid |
| Colour | white to very faintly yellow |
| Solubility | 1 M HCl: soluble50 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-25-36/37/38-42/43 |
| Safety statements (S) | 53-22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... GABBR1(2550), GABBR2(9568)rat ... Gabbr1(81657), Gabra2(29706) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (±)-Baclofen used for?
+
(±)-Baclofen is used primarily in neuroscience research as a GABAB receptor agonist to study muscle relaxant and antispasmodic effects, and to investigate neuronal pathways and neurotransmission.
What are the CAS number and molecular formula for (±)-Baclofen?
+
(±)-Baclofen has the CAS number 1134-47-0 and the empirical formula C10H12ClNO2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (±)-Baclofen with an assay of ≥98% (TLC). This product is intended for research and laboratory use and is not supplied as USP, BP, or EP grade.
What are the safety considerations for handling (±)-Baclofen?
+
(±)-Baclofen presents significant hazards. It is toxic if swallowed (H301), causes skin irritation (H315), may cause an allergic skin reaction (H317), causes serious eye irritation (H319), may cause allergy or asthma symptoms or breathing difficulties if inhaled (H334), may cause respiratory irritation (H335), and may damage fertility or the unborn child (H360). Appropriate personal protective equipment, including eye/face protection and respiratory protection, must be used. Handle in a well-ventilated area.
How is (±)-Baclofen packed, shipped, and exported?
+
Tech Serve Solutions packs (±)-Baclofen securely according to chemical safety regulations. We are experienced global suppliers and exporters of fine chemicals, accommodating various international shipping requirements.
How can I request a sample or quote for (±)-Baclofen?
+
To request a sample or a quotation for (±)-Baclofen, please contact our sales team through the website or by direct inquiry, providing your specific requirements.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis